Advertisement

Neutrophilic Erythrophagocytosis in MDS-MLD

  • P. S. Shobhanaa
  • Naveen KakkarEmail author
Correspondence
  • 7 Downloads

Dear Sir

An 85 years old male presented with generalized weakness and numbness of feet since 6 months. Complete blood count (CBC) showed pancytopenia (Hemoglobin-96 g/l, WBC-2.5 × 10 9/l) and platelets-47 × 10 9/l with an absolute neutrophil count of 0.675 × 10 9/l). Peripheral blood smear showed mild dysgranulopoiesis with few pelgeroid neutrophils. Bone marrow aspirate smears were hypercellular and showed marked erythroid hyperplasia (Myeloid: Erythroid ratio = 1:2.4). There was borderline (10%) dyserythropoiesis with significant dysgranulopoiesis (17%) and dysmegakaryopoiesis (40%). Few neutrophils (5 per 10 oil immersion fields) showed erythrophagocytosis (Fig.  1a, b) with engulment of mature red cells while others showed dysplastic changes with pelgeroid forms (Fig.  1 c, arrow) and hypogranularity. Rare erythroblasts also showed engulfment of RBCs (Fig.  1d). No ring sideroblasts were seen. There was no significant increase in blasts (2%) on aspirate smears or trephine biopsy. The...

Notes

Compliance with Ethical Standards

Ethical Approval

No animals were used in this study. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was not taken as this is an image based report with no patient intervention specific to the study.

References

  1. 1.
    Lee JH (2017) A rare case of erythrophagocytosis by neutrophils on the peripheral blood smear. Blood Res 52:74–75CrossRefGoogle Scholar
  2. 2.
    Shi M, Chen D (2017) Erythrophagocytosis by neutrophils and megakaryocytic emperipolesis are distinctive morphologic features in del(20q)-associated myelodysplastic syndrome. Hum Pathol Case Rep 8:69–70CrossRefGoogle Scholar
  3. 3.
    Komrokji RS, Kulasekararaj A, Al Ali NH, Kordasti S, Bart-Smith E, Craig BM et al (2016) Autoimmune diseases and myelodysplastic syndromes. Am J Hematol 91:E280–E283CrossRefGoogle Scholar
  4. 4.
    Mekinian A, Grignano E, Braun T, Decaux O, Liozon E, Costedoat-Chalumeau N et al (2016) Systemic inflammatory and autoimmune manifestations associated with myelodysplastic syndromes and chronic myelomonocytic leukaemia: a French multicentre retrospective study. Rheumatology (Oxford) 55:291–300CrossRefGoogle Scholar
  5. 5.
    Wolach O, Stone R (2016) Autoimmunity and inflammation in myelodysplastic syndromes. Acta Haematol 136:108–117CrossRefGoogle Scholar

Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  1. 1.Department of PathologyChristian Medical College and HospitalLudhianaIndia

Personalised recommendations