Langerhans Histiocytosis Renders a Differential and Complementary Diagnosis for a Sjögren Syndrome Female Presenting with a Hypophyseal Mass, Pulmonary Emphysema and Thyroid Nodules

  • Shuo Li
  • Lu ZhangEmail author
  • Minghui Duan
  • Wenqin Li
  • Yingying Yang

Dear editor,

A 35-year-old female with 18 months of mouth and eye dryness, polyuria, polydipsia, amenorrhoea, several papules on the chest skin and 6 months of galactorrhea was referred to the outpatient department. Her peripheral blood sample indicated prolactin 57.84 ng/ml, follicle stimulating hormone 1.42 IU/L, luteinizing hormone 0.22 IU/L, estradiol 15.00 pg/ml; positive antinuclear antibody testing at 1:320 in a speckled pattern and positive anti-SSA. Physical examination revealed diffuse bilateral thyroid enlargement and triggering ivory lactation of bilateral breasts.

MRI demonstrated abnormal mass in the hypophysis funnel-area, about 9.0 × 6.9 × 9.5 mm with compression of optic chiasma. Water-deprivation test was positive. Ophthalmology examinations revealed positive Schirmer’s test and shortened tear break-up time (right 4 s, left 4 s). The unstimulated whole salivary flow rate was 0.02 mL/min. Histologic sections of salivary gland indicated the infiltration of lymphocytes...


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Conflict of interest

Authors declare that they have no conflict of interest.


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Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  • Shuo Li
    • 1
  • Lu Zhang
    • 2
    Email author
  • Minghui Duan
    • 2
  • Wenqin Li
    • 3
  • Yingying Yang
    • 1
  1. 1.Department of Endocrinology, Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  2. 2.Department of HematologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina
  3. 3.Department of pathologyAffiliated Tumor Hospital of Xinjiang Medical UniversityUrumqiChina

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