Diffuse Large B-Cell Lymphoma: A Rare Cause of Lung Consolidation
Diffuse large B-cell lymphoma (DLBCL) is the commonest sub-type of non-Hodgkin lymphoma. However, lung consolidation is a rare presentation of DLBCL. Moreover, in view of poor general condition, it poses clinical dilemma of when to start chemotherapy and whether chemotherapy should be given at full dose or truncated doses till improvement in general condition. A 48-years-old lady was admitted with complaints of non-productive cough for 2 months duration. She was febrile and hypoxemic requiring oxygen supplementation. She had bilateral axillary lymphadenopathy, and bronchial breath sounds on chest auscultation. Chest X-ray showed non-homogenous opacities involving bilateral lower zones. A diagnosis of DLBCL was confirmed on lymph node biopsy and Immunohistochemistry. She received chemotherapy, following which a gradual, improvement in her breathlessness and cough was noted over ensuing week and she got discharged from the hospital and received rest of her chemotherapy on outpatient basis. In a case of DLBCL with lung consolidation, a high index of suspicion can clinch the diagnosis of secondary lymphomatous involvement. Presence of respiratory failure at presentation doesn’t necessarily warrants truncation of chemotherapy doses.
KeywordsLymphoma Pneumonia Infection Emergency medicine Chemotherpy Imaging
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
Informed signed written consent was taken from the patient involved.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Human and Animals Rights
No animals were involved in the study.
- 4.Malhotra P (2011) Hematopoietic and lymphoid neoplasm of lungs. In: Jindal SK (ed) Text book of pulmonary medicine: a developing countries perspective, 1st edn. Jaypee Brothers Medical Publishers (P) Ltd, New DelhiGoogle Scholar