Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma in India

  • Rahul NaithaniEmail author
  • Nitin Dayal
  • Reeta Rai
  • Sangeeta Pathak
  • Manoj Singh

To the Editor,

There is lack of data on multiple myeloma (MM) transplants from India [1]. In this regard, we read article by Malhotra et al. [2] with interest and will like to share our data.

Over last 5 years 60 autologous hematopoietic stem cell transplant (HSCT) were performed for 55 patients (21 females) with MM. Five patients underwent tandem autologous BMT and were excluded. Data on remaining 50 patients are presented. Stem cells were stored in blood bank refrigerator at 4 °C. CD34 cell enumeration was performed using ISHAGE protocol [3].

Transplant parameters are outlined in Table  1. Median age was 56 years (36–68 years). Thirty-one patients were in complete remission (CR), 3 had very good partial remission (VGPR), 15 had partial remission (PR) and 1 had active disease at the time of transplant. Peripheral blood stem cell apheresis were performed using Hemonetics MCS + or Cobe spectra apheresis machine using double lumen central venous catheter. Melphalan 140 mg/m 2was used in...


Compliance with Ethical Standards

Conflict of interest

The author declares that they have no conflict of interest.

Ethical Approval

The study was approved by Institutes’ Ethics Committee.


  1. 1.
    Kumar L, Boya RR, Pai R et al (2016) Autologous stem cell transplantation for multiple myeloma: long-term results. Natl Med J India 29(4):192–199PubMedGoogle Scholar
  2. 2.
    Malhotra P, Yanamandra U, Khadwal A et al (2017) Autologous stem cell transplantation for multiple myeloma: single centre experience from North India. Indian J Hematol Blood Transfus. CrossRefPubMedPubMedCentralGoogle Scholar
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    Naithani R, Dayal N, Dixit G (2017) Single versus dual platform analysis for hematopoietic stem cell enumeration using ISHAGE protocol. Indian J Hematol Blood Transfus 33(3):370–374CrossRefPubMedGoogle Scholar
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    Prinja S, Kaur G, Malhotra P et al (2017) Cost-effectiveness of autologous stem cell treatment as compared to conventional chemotherapy for treatment of multiple myeloma in India. Indian J Hematol Blood Transfus 33(1):31–40CrossRefPubMedPubMedCentralGoogle Scholar
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    Kumar R, Kapoor R, Asthana B et al (2017) Single dose preemptive plerixafor for stem cell mobilization for ASCT after lenalidomide based therapy in multiple myeloma: impact in resource limited setting. Indian J Hematol Blood Transfus 33(4):463–469CrossRefPubMedGoogle Scholar

Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  1. 1.Division of Hematology and Bone Marrow TransplantationMax Superspeciality HospitalNew DelhiIndia
  2. 2.Department of Lab MedicinesMax Superspeciality HospitalNew DelhiIndia
  3. 3.Department of Transfusion MedicineMax Superspeciality HospitalNew DelhiIndia

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