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Can Exchange Transfusions Using Red Blood Cells from Donors with Hemoglobin E Trait Prevent or Ameliorate Severe Malaria in Patients with Multi-drug Resistant Plasmodium falciparum?

  • Ryan P. Jajosky
  • Audrey N. Jajosky
  • Philip G. Jajosky
Correspondence
  • 18 Downloads

Notes

Compliance with ethical standards

Conflict of interest

Ryan Jajosky is the CEO and part-owner of Biconcavity Inc. Philip Jajosky is CFO and part-owner of Biconcavity Inc, a biotechnology research and development company exploring drug-linked-erythrocytes. This company does not have any interest in Hemoglobin E or malaria.

References

  1. 1.
    World Health Organization (2016) World malaria report 2016. World Health Organization, GenevaCrossRefGoogle Scholar
  2. 2.
    Jajosky RP, Jajosky AN, Jajosky PG (2017) Can exchange transfusions using red blood cells from donors with Southeast Asian ovalocytosis prevent or ameliorate cerebral malaria in patients with multi-drug resistant Plasmodium falciparum? Transfus Apher Sci 56:865CrossRefPubMedGoogle Scholar
  3. 3.
    Colah R, Gorakshakar A, Nadkarni A (2010) Global burden, distribution and prevention of β-thalassemias and hemoglobin E disorders. Expert Rev Hematol 3:103–117CrossRefPubMedGoogle Scholar
  4. 4.
    Sikdar M (2016) Hemoglobin E in Northeast India: a review on its origin, distribution, migration and health implication. Anthropol Rev 79:241–263CrossRefGoogle Scholar
  5. 5.
    Chotivanich K, Udomsangpetch R, Pattanapanyasat K (2002) Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P. falciparum malaria. Blood 100:1172–1176PubMedGoogle Scholar

Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  • Ryan P. Jajosky
    • 1
  • Audrey N. Jajosky
    • 2
  • Philip G. Jajosky
    • 1
  1. 1.Biconcavity IncLilburnUSA
  2. 2.Pathology Department, University Hospitals Cleveland Medical CenterCase Western Reserve UniversityClevelandUSA

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