Advertisement

Double Dose Plateletpheresis: A Savior to Shrinking Donor Pool and Platelet Inventory Management

  • R. N. Makroo
  • Dhaval Fadadu
  • Soma Agrawal
  • Mohit Chowdhry
Original Article
  • 38 Downloads

Abstract

The double dose plateletpheresis (DDP) is considered to be a cost effective way of preparing platelets, owing to the low incidence of infectious complications and by also minimizing allogeneic donor exposure to the patients. We aimed at collecting DDP at our center and study its effect on donor hematological parameters, evaluate the product quality and the adverse donor reactions thereafter. Double Dose Platelet was collected from 160 eligible apheresis donors on Amicus cell separator (Fenwal, Inc. Three Corporate Drive Lake Zurich, IL, USA). The donor hematological parameters, product yield, adverse effects on the donors, collection efficiency (CE) and collection rate of the machine were noted. A total of 160 DDPs were collected. The total blood volume processed to achieve the yield of 6.0 × 1011 was 3673.5 ± 276.56 mL. The average yield achieved was 6.14 ± 0.26 × 1011. The average run time was 68.05 ± 6.25 min. Total ACD used was 408.33 ± 33.81 mL. We observed significant relation of pre-donation donor platelet count and platelet yield (p < 0.001). The CE was 78.09 ± 5.15%. There was a significant drop in the post DDP platelet count (p < 0.01) causing no adverse effect. Fourteen donors (8.75%) experienced mild citrate related adverse events. DDP does not lead to major adverse effects and post DDP hematological parameters are also within the acceptable range. It also helps to maintain apheresis platelet inventory, reduce donor exposure, reduce donor requirement and reduce the cost of the product.

Keywords

Apheresis Double dose apheresis Plateletpheresis Donor selection criteria 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors have no conflict of interest.

Ethical Approval

All procedures performed in this study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

References

  1. 1.
    Fontana S, Kellerb P, Taleghanib MB (2011) Platelet recruitment during multiple donor plateletapheresis differs between cell separators. Transfus Med Hemother 38:195–198CrossRefGoogle Scholar
  2. 2.
    Grifols-Lucas JA (1952) Use of plasmapheresis in blood donors. BMJ 1:854CrossRefGoogle Scholar
  3. 3.
    Freireich EJ, Judson G, Levin RH (1965) Separation and collection of leukocytes. Cancer Res 25:1516–1520PubMedGoogle Scholar
  4. 4.
    Snyder EL, Elfath MD, Taylor H, Taylor H, Rugg N, Greenwalt TJ, Baril L, Whitley P, Brantigan B, Story K (2003) Collection of two units of leukoreduced RBCs from a single donation with a portable multiple-component collection system. Transfusion 43:1695–1705CrossRefGoogle Scholar
  5. 5.
    Wollersheim J, Dautzenberg M, van de Griendt A, Sybesma B (2006) Donor selection criteria to maximize double platelet components (DPP) by platelet apheresis. Transfus Apher Sci 34:179–186CrossRefGoogle Scholar
  6. 6.
    Das SS, Chaudhary R, Verma SK, Ojha S, Khetan D (2009) Pre- and post- donation haematological values in healthy donors undergoing plateletpheresis with five different systems. Blood Transfus 7(3):188–192PubMedPubMedCentralGoogle Scholar
  7. 7.
    Zingsem J (2010) Multicomponenet apheresis. ISBT Sci Ser 5:83–87CrossRefGoogle Scholar
  8. 8.
    Picker SM, Radojska SM, Gathof BS (2006) Evaluation of concurrent collection of in-line filtered platelets and packed red blood cells by multicomponent apheresis with three last-generation apparatuses. Vox Sang 91:47–55CrossRefGoogle Scholar
  9. 9.
    Julmy F, Ammann RA, Mansouri Taleghani B, Fontana S, Hirt A, Leibundgut K (2008) Effects of high-yield thrombocytapheresis on the quality of platelet components. Transfusion 48:442–450CrossRefGoogle Scholar
  10. 10.
    Richa E, Krueger P, Burgstaler EA, Bryant SC, Winters JL (2008) The effect of double- and triple-apheresis platelet component donation on apheresis donor platelet and white blood cell counts. Transfusion 48:1325–1332CrossRefGoogle Scholar
  11. 11.
    Gurak S, Arslan O (2007) Efficacy of Fenwal Amicus blood cell separator in double dose platelet collection. Transfus Apher Sci 36:69–72CrossRefGoogle Scholar
  12. 12.
    Food and Drug Administration (2007) Guidance for industry and FDA review staff: collection of platelets by automated methods. U.S. Department of Health and Human Services, Washington DC, pp 1–3Google Scholar
  13. 13.
    Malik V (2001) Drugs & cosmetics act, 13th edn. Eastern Book Company, LucknowGoogle Scholar
  14. 14.
    Das SS, Chaudhary R, Verma SK, Ojha S, Khetan D (2009) Pre and post donation hematological values in healthy donors undergoing plateletpheresis with five different systems. Blood Transfus 7:188–192PubMedPubMedCentralGoogle Scholar
  15. 15.
    Price TH (2003) Provision of single-donor platelet transfusions: patient and producer perspectives. In: McLeod BC, Price TH, Weinstein R (eds) Apheresis: principles and practice, 2nd edn. AABB Press, Bethesda, pp 185–197Google Scholar
  16. 16.
    Vassallo R, Murphy S (2003) Platelet function, kinetics and metabolism: impact on quality assessment, storage and clinical use. In: McLeod BC, Price TH, Weinstein R (eds) Apheresis: principles and practice, 2nd edn. AABB Press, Bethesda, pp 161–183Google Scholar
  17. 17.
    Ness P, Braine H, King K, Barrasso C, Kickler T, Fuller A et al (2001) Single donor platelets reduce the risk of septic platelet transfusion reactions. Transfusion 41:857–861CrossRefGoogle Scholar
  18. 18.
    Ness PM, Campbell-Lee SA (2001) Single donor versus pooled random donor platelet concentrates. Curr Opin Hematol 8:392–396CrossRefGoogle Scholar
  19. 19.
    Singh RP, Marwaha N, Malhotra P, Dash S (2009) Quality assessment of platelet concentrates prepared by platelet rich plasma-platelet concentrate, buffy coat poor-platelet concentrate (BC-PC) and apheresis-PC methods. Asian J Transfus Sci 3(2):86–94CrossRefGoogle Scholar
  20. 20.
    Stainsby D, Jones H, Asher D, Atterbury C, Boncinelli A, Brant L, Chapman CE, Davison K, Gerrard R, Gray A, Knowles S, Love EM, Milkins C, McClelland DB, Norfolk DR, Soldan K, Taylor C, Revill J, Williamson LM, Cohen H (2006) Serious hazards of transfusion: a decade of hemovigilance in the UK. Transfus Med Rev 20:273–282CrossRefGoogle Scholar
  21. 21.
    Kleinmann S, Grossman B, Kopko P (2010) A national survey of transfusion-related acute lung injury risk reduction policies for platelets and plasma in the United States. Transfusion 50:1312–1321CrossRefGoogle Scholar
  22. 22.
    Glicher RO, Smith JW (eds) (2009) Apheresis: principles and technologies of hemapheresis. In: Simon LT, Snyder EL, Solheim BG, Stowell CP, Strauss RG, Petrides M (eds) Rossi‘s principle of transfusion medicine, 4th edn. Blackwell Publishing Ltd, pp 617–628Google Scholar
  23. 23.
    Chaudhary R, Das SS, Khetan D, Ojha S, Verma S (2010) Donor safety issue in high-dose platelet collection using the latest apheresis system. Transfus Altern Transfus Med 11:1–7CrossRefGoogle Scholar
  24. 24.
    Jaipian J, Chuansumrit A, Chongkolwatana V, Kunakorn M, Kitpoka P (2013) Collection efficacies of double dose platelet by blood cell separators. J Hematol Transfus Med 23:121–128CrossRefGoogle Scholar
  25. 25.
    Fontana S, Mordasini L, Keller P, Taleghani BM (2006) Prospective, paired crossover comparison of multiple, single-needle plateletpheresis procedures with the Amicus and Trima Accel cell separators. Transfusion 46:2004–2010CrossRefGoogle Scholar
  26. 26.
    Keklik M, Eser B, Kaynar L, Solmaz M, Ozturk A, Yay M, Birekul A, Oztekin M, Sivgin S, Cetin M, Unal A (2014) Comparison of double dose plateletpheresis on the Fenwal Amicus, Fresenius COM.TEC and Trima Accel cell separators. Transfus Apher Sci 51:193–196CrossRefGoogle Scholar
  27. 27.
    Flesch BK, Adamzik I, Steppat D, Miller J, Carstensen L, Schapke M, Davey J (2010) Paired crossover study of tw o plateletpheresis systems concerning platelet component quality and donor comfort. Transfusion 50:894–901CrossRefGoogle Scholar

Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  1. 1.Department of Transfusion Medicine, Molecular Biology and Transplant ImmunologyIndraprastha Apollo HospitalNew DelhiIndia

Personalised recommendations