Leukemia in Patients with Klinefelter Syndrome: A Report of Two Cases

  • M. Bchir
  • W. Ayed
  • H. Ben Neji
  • O. Kilani
  • S. Kefi
  • M. Zarrouk
  • H. Guermani
  • S. Hentati
  • A. Amouri
  • B. Meddeb
Short Communication
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Abstract

Klinefelter syndrome (KS) is a chromosome abnormality characterized by a 47, XXY karyotype associated with hypogonadism and infertility. We present two cases of leukemia in patients with KS. The first patient presented with acute promyelocytic leukemia. He relapsed after the end of treatment. The second patient was diagnosed with chronic myeloid leukemia. Treatment with imatinib failed and the patient presented with myeloid blast crisis.

Keywords

Klinefelter syndrome Acute promyelocytic leukemia Chronic myelogenous leukemia Karyotype 
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Notes

Acknowledgements

Dr. Wiem AYED, Olfa KILANI and Ahlem AMOURI made the cytogenetic analysis for the two patients.

Compliance with Ethical Standards

Conflicts of interest

No conflict-of-interest.

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Copyright information

© Indian Society of Haematology & Transfusion Medicine 2015

Authors and Affiliations

  • M. Bchir
    • 1
  • W. Ayed
    • 2
  • H. Ben Neji
    • 1
  • O. Kilani
    • 2
  • S. Kefi
    • 1
  • M. Zarrouk
    • 1
  • H. Guermani
    • 2
  • S. Hentati
    • 2
  • A. Amouri
    • 2
  • B. Meddeb
    • 1
  1. 1.Department of HematologyAziza Othmana University HospitalTunisTunisia
  2. 2.Laboratory of Histology and Cytogenetics, Department of Histology and Cytogenetics, Faculty of Medicine of Tunis, Institut Pasteur de TunisEl Manar Tunis UniversityTunisTunisia

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