Fungal Mycotic Aneurysm in a Case of Acute Lymphoblastic Leukemia

  • Kamal Kant Sahu
  • Uday Yanamandra
  • Rishi Dhawan
  • Alka Khadwal
  • S. S. Dhandapani
  • Pankaj Malhotra
Case Report


We report a case of a 15-year old boy who was managed as a case of B cell lymphoblastic leukaemia with the modified BFM 90 protocol. During the induction phase, he developed febrile neutropenia with sino-pulmonary fungal infection confirmed on histopathology. He developed left sided hemiparesis during in-hospital management of febrile neutropenia. Neuroimaging revealed 9.6 × 8.4 mm round well defined aneurysm arising from right cortical artery in distal middle cerebral artery territory. He underwent fronto-temporo-parietal craniectomy with evacuation of the hematoma and excision of the aneurysm. Histopathological examination of excised aneurysmal specimen grew same species of fungus as was cultured from nasal scraping. He recovered fully in next 6 months with minimal residual focal neurological deficits. Presently he is in maintenance phase chemotherapy. We presented this case to illustrate a rare complication of ALL therapy with mycotic aneurysm secondary to invasive fungal infection treated successfully.


Acute Lymphoblastic Leukemia Febrile Neutropenia Voriconazole Infective Endocarditis Intracranial Aneurysm 
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This study was not funded by any institution or authority.

Compliance with Ethical Standards

Conflict of interest

None of the authors have any conflict of interest to mention.

Ethical approval

This article does not contain any studies with animals performed by any of the authors. This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from the participant included in the study.


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Copyright information

© Indian Society of Haematology & Transfusion Medicine 2015

Authors and Affiliations

  • Kamal Kant Sahu
    • 1
  • Uday Yanamandra
    • 1
  • Rishi Dhawan
    • 1
  • Alka Khadwal
    • 1
  • S. S. Dhandapani
    • 2
  • Pankaj Malhotra
    • 1
  1. 1.Department of Clinical Haematology, Internal MedicinePostgraduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of NeurosurgeryPostgraduate Institute of Medical Education and ResearchChandigarhIndia

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