Atypical Presentation of Acute Lymphoblastic Leukemia in a 7 Year Old Child
Case Report
First Online:
Received:
Accepted:
- 152 Downloads
Abstract
Seven year child, who had intussusception 4 month before, readmitted for fever and walking difficulty. On examination, child had mild pallor and kyphosis of the spine but no organomegaly, lymphadenopathy or bone pain . Further evaluation revealed hypercalcemia, diffuse osteoporosis with vertebral fracture. Peripheral smear showed no blasts or pancytopenia. Bone marrow aspiration turned out to be a pre B cell ALL. This child had many atypical presentations like intussusception, osteoporosis, vertebral collapse and hypercalcemia without any classical features of ALL.
Keywords
Acute lymphoblastic leukemia Osteoporosis Hypercalcemia IntussusceptionsReferences
- 1.Salim H et al (2014) Osteoporosis resulting from acute lymphoblastic leukemia in a 7-year-old boy: a case report. J Med Case Rep. 8:168CrossRefPubMedPubMedCentralGoogle Scholar
- 2.Sadawaite S et al (2008) An unusual presentation of pediatric acute lymphoblastic leukemia. Indian J Hematol Blood Transfus 24(2):59–62CrossRefPubMedPubMedCentralGoogle Scholar
- 3.Brix N, Rosthoj S (2014) Bone marrow involvement is not manifest in the early stages of childhood acute lymphoblastic leukaemia. Dan Med J 61(8):A4883PubMedGoogle Scholar
- 4.Riccio I et al (2013) Musculoskeletal problems in pediatric acute leukemia. J Pediatr Orthop B 22(3):264–269CrossRefPubMedGoogle Scholar
- 5.Haddy TB, Mosher RB, Reaman GH (2001) Osteoporosis in survivors of acute lymphoblastic leukemia. Oncologist 6(3):278–285CrossRefPubMedGoogle Scholar
- 6.Cohan N et al (2011) Initial presentation of acute lymphoblastic leukemia with osteoporosis and multiple spontaneous bone fractures. Iran Red Crescent Med J 13(1):52–54PubMedPubMedCentralGoogle Scholar
- 7.Lane SW (2012) Bad to the bone. Blood 119(2):323–325CrossRefPubMedGoogle Scholar
- 8.Das A, Bansal D, Kumar N (2014) Acute lymphoblastic leukemia mimicking metabolic bone disease. Indian J Pediatr 81(8):827–828CrossRefPubMedGoogle Scholar
- 9.Kolyva S et al (2014) Hypercalcemia and osteolytic lesions as presenting symptoms of acute lymphoblastic leukemia in childhood. The use of zoledronic acid and review of the literature. J Pediatr Endocrinol Metab 27(3–4):349–354PubMedGoogle Scholar
- 10.Gurney JG et al (2014) Bone mineral density among long-term survivors of childhood acute lymphoblastic leukemia: results from the St. Jude Lifetime Cohort Study. Pediatr Blood Cancer 61(7):1270–1276CrossRefPubMedPubMedCentralGoogle Scholar
- 11.Sinigaglia R et al (2008) Musculoskeletal manifestations in pediatric acute leukemia. J Pediatr Orthop 28(1):20–28CrossRefPubMedGoogle Scholar
- 12.Halton J et al (2009) Advanced vertebral fracture among newly diagnosed children with acute lymphoblastic leukemia: results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) research program. J Bone Miner Res 24(7):1326–1334CrossRefPubMedPubMedCentralGoogle Scholar
- 13.Kumari TP et al (1998) Intussusception at the onset of acute lymphoblastic leukemia in a child. Indian Pediatr 35(5):470–472PubMedGoogle Scholar
Copyright information
© Indian Society of Haematology & Transfusion Medicine 2015