Primary Plasma Cell Leukaemia with Unusual Presentations: A Case Series

  • Urmila Majhi
  • Kanchan Murhekar
  • Shirley Sundersingh
  • K. R. Rajalekshmi
Case Report
First Online:
Received:
Accepted:

Abstract

We present here three cases of plasma cell dyscrasias; first case presenting as primary plasma cell leukemia showing unusual morphology and aberrant expression of myeloid markers; the second case presenting as plasma cell leukaemia with atypical plasma cells in peripheral blood and the third case presenting as myelomatous pleural effusion after treatment for myeloma.

Keywords

Plasma cell leukemia Aberrant expression Myeolomatous pleural effusion 
This is a preview of subscription content, log in to check access.

Notes

Conflict of interest

None declared.

References

  1. 1.
    Panizo C, Cuesta B, Rocha E (1998) Primary plasma cell leukemia with unusual morphology and complex karyotype. Haematologica 83:849–850PubMedGoogle Scholar
  2. 2.
    Gertz MA, Buadi FK (2010) Plasma cell leukemia. Haematologica 95:705–707PubMedCrossRefPubMedCentralGoogle Scholar
  3. 3.
    Fernández de Larrea C, Kyle RA et al (2013) Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group. Leukemia 27:780–791PubMedCrossRefGoogle Scholar
  4. 4.
    Zukerberg LR, Ferry JA, Conlon M, Harris NL (1990) Plasma cell myeloma with cleaved, multilobated, and monocytoid nuclei. Am J Clin Pathol 93:657–661PubMedGoogle Scholar
  5. 5.
    Shin JS, Stopyra GA, Warhol MJ, Multhaupt HA (2001) Plasmacytoma with aberrant expression of myeloid markers, T-cell markers, and cytokeratin. J Histochem Cytochem 49:791–792PubMedCrossRefGoogle Scholar
  6. 6.
    Sher T, Miller KC, Deeb G, Lee K, Chanan-Khan A (2010) Plasma cell leukaemia and other aggressive plasma cell malignancies. Br J Haematol 150:418–427PubMedCrossRefPubMedCentralGoogle Scholar
  7. 7.
    Kim YM, Lee KK, Oh HS et al (2000) Myelomatous effusion with poor response to chemotherapy. J Korean Med Sci 15:243–246PubMedCrossRefPubMedCentralGoogle Scholar
  8. 8.
    Shirdel A, Attarn D, Ghobadi H, Ghiasi T (2007) Myelomatous pleural effusion. Tanaffos 6:68–72Google Scholar
  9. 9.
    Athanasiou E, Kaloutsi V, Kotoula V et al (2001) A morphologic, immunohistochemical, and in situ hybridization study of 71 paraffin-embedded bone marrow biopsy specimens. Am J Clin Pathol 116:535–542PubMedCrossRefGoogle Scholar
  10. 10.
    Pagano L, Valentini CG, De Stefano V et al (2011) Primary plasma cell leukemia: a retrospective multicenter study of 73 patients. Ann Oncol 22:1628–1635PubMedCrossRefGoogle Scholar
  11. 11.
    Colovic´ M, Jankovic´ G, Suvajdzic´ N et al (2008) Thirty patients with primary plasma cell leukemia: a single center experience. Med Oncol 25:154–160PubMedCrossRefGoogle Scholar

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2014

Authors and Affiliations

  • Urmila Majhi
    • 1
  • Kanchan Murhekar
    • 1
  • Shirley Sundersingh
    • 1
  • K. R. Rajalekshmi
    • 1
  1. 1.Department of OncopathologyCancer Institute (WIA)ChennaiIndia

Personalised recommendations