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Precursor NK Cell Lymphoblastic Leukemia/Lymphoma—Report of a Case with Literature Review

  • Sonal JainEmail author
  • Rajiv Kumar
  • Abhishek Purohit
  • Hara Prasad Pati
Case Report

Abstract

Precursor Natural Killer (NK) cell lymphoblastic leukemia/lymphoma is a rare entity defined clearly by WHO (2008 WHO classification). However, the pathobiology of this subset of neoplasms is not clearly defined. There is wide disparity in the literature regarding the nomenclature and diagnostic criteria used to diagnose and characterize acute leukemias of presumed NK cell origin. In the present article we report a case of Precursor NK cell lymphoblastic leukemia/lymphoma and review the cases reported after 2008 WHO classification came into vogue, as acute leukemias of NK cell origin.

Keywords

Natural killer Leukemia Precursor 

Supplementary material

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References

  1. 1.
    Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds) (2008) WHO Classification of tumours of hematopoietic and lymphoid tissues. IARC, LyonGoogle Scholar
  2. 2.
    Guan XQ, Xu L, Ke ZY, Huang LB, Zhang XL, Zhang YC, Luo XQ (2011) Five Chinese pediatric patients with leukemias possibly arising from immature natural killer cells: clinical features and courses. Pediatr Hematol Oncol 28(3):187–193PubMedGoogle Scholar
  3. 3.
    Owatari S, Otsuka M, Takeshita T, Mizukami K, Suzuki S, Uozumi K et al (2009) Uncommon cases of immature type CD56 + natural killer (NK)-cell neoplasms, characterized by expression of myeloid antigen of blastic NK-cell lymphoma. Int J Hematol 89(2):188–194PubMedCrossRefGoogle Scholar
  4. 4.
    Hashii Y, Okuda T, Ohta H, Ozono K, Hara J (2010) Pediatric myeloid/NK cell precursor lymphoma/leukemia expressing T/NK immunophenotype markers. Int J Hematol 91:525–529PubMedCrossRefGoogle Scholar
  5. 5.
    Chen B, Xu X, Ji M, Lin G (2009) Myeloid/NK cell acute leukemia. Int J Hematol 89:365–367PubMedCrossRefGoogle Scholar
  6. 6.
    Ma Y, Chen B, Xu X, Lin G (2009) Myeloid/natural killer cell precursor acute leukemia with multiple subcutaneous nodules as the initial presentation: a case report and literature review. Int J Hematol 90(2):243–247PubMedCrossRefGoogle Scholar
  7. 7.
    Suzuki R, Ohtake S, Takeuchi J, Nagai M, Kodera Y, Hamaguchi M et al (2010) The clinical characteristics of CD7 + CD56 + acute myeloid leukemias other than M0. Int J Hematol 91(2):303–309PubMedCrossRefGoogle Scholar
  8. 8.
    Dalmazzo LF, JAcomo RH, Marinato AF, Figueiredo-Pontes LL, Cunha RL, Garcia AB et al (2009) The presence of CD56/CD16 in T-cell acute lymphoblastic leukemia correlates with the expression of cytotoxic molecules and is associated with worse response to treatment. Br J Hematol 144(2):223–229CrossRefGoogle Scholar

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2014

Authors and Affiliations

  • Sonal Jain
    • 1
    Email author
  • Rajiv Kumar
    • 1
  • Abhishek Purohit
    • 1
  • Hara Prasad Pati
    • 1
  1. 1.Department of HematologyAll India Institute of Medical SciencesNew DelhiIndia

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