Morphological Spectrum of Paroxysmal Nocturnal Hemoglobinuria (PNH)




Author would like to acknowledge Indian Council of Medical Research for supporting the study.

Conflict of interest



  1. 1.
    Hillmen P, Lewis SM, Bessler M, Luzzatto L, Dacie JV (1995) Natural history of paroxysmal nocturnal haemoglobinuria. N Engl J Med 333:1253–1258CrossRefPubMedGoogle Scholar
  2. 2.
    de Latour RP, Mary JY, Salanoubat C, French Society of Hematology, French Association of Young Hematologists et al (2008) Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories. Blood 112(8):3099–3106CrossRefPubMedGoogle Scholar
  3. 3.
    Mukhina GL, Buckley JT, Barber JP, Jones RJ, Brodsky RA (2001) Multilineage glycosylphosphatidylinositol anchor deficient hematopoiesis in untreated aplastic anemia. Br J Haematol 115:476–482CrossRefPubMedGoogle Scholar
  4. 4.
    Masako I, Koichi F, Tatsuhiko A (1998) Paroxysmal nocturnal clone in patients with myelodysplastic syndrome. Br J Hematol 102(2):465–474CrossRefGoogle Scholar
  5. 5.
    Parker C, Omine M, Richards S, Nishimura J-I, Bessler M, Ware R, Hillmen P, Luzzatto L, Young N, Kinoshita T, Rosse W, Socie G, International PNH Interest Group (2005) Diagnosis and management of paroxysmal nocturnal haemoglobinuria. Blood 106:3699–3709CrossRefPubMedCentralPubMedGoogle Scholar
  6. 6.
    Moyo VM, Mukhina GL, Garrett ES, Brodsky RA (2004) Natural history of paroxysmal nocturnal haemoglobinuria using modern diagnostic assays. Br J Haematol 126(1):133–138CrossRefPubMedGoogle Scholar
  7. 7.
    Nishimura JI, Kanakura Y, Ware RE et al (2004) Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. Medicine (Baltimore) 83:193–207CrossRefGoogle Scholar
  8. 8.
    Brodsky RA (2006) New insights into paroxysmal nocturnal hemoglobinuria. Hematol Am Soc Hematol Educ Program 516:24–28CrossRefGoogle Scholar
  9. 9.
    Richards SJ, Rawstron AC, Hillmen P (2000) Application of flow cytometry to the diagnosis of paroxysmal nocturnal hemoglobinuria. Cytometry 42:223–233CrossRefPubMedGoogle Scholar
  10. 10.
    Pu JJ, Mukhina G, Wang H, Savage WJ, Brodsky RA (2011) Natural history of paroxysmal nocturnal haemoglobinuria clones in patients presenting as aplastic anaemia. Eur J Haematol 87:37–45CrossRefPubMedCentralPubMedGoogle Scholar
  11. 11.
    Sigimori C, Chujho T, Feng X et al (2006) Minorpopulation of CD55-CD59 blood cells predicts response to immunosuppressive therapy and prognosis ia patients with aplastic anemia. Blood 107:1308–1314CrossRefGoogle Scholar
  12. 12.
    Hu R, Mukhina Gl, Piantadosi S, Barber JP, Jones RJ, Brodsky RA (2005) PIG-A mutation in normal haemopoiesis. Blood 105:3848–3854CrossRefPubMedCentralPubMedGoogle Scholar
  13. 13.
    Ghosh K (1994) How immature is the abnormal stem cell in paroxysmal nocturnal hemoglobulinuria? Am J Hematol 47:245CrossRefPubMedGoogle Scholar
  14. 14.
    Savage WJ, Barber Jp, Mukhina GL et al (2009) Glycosyl phosphatidylinositol-anchored protein deficiency confers resistance to apoptosis in PNH. Exp Hematol 37:42–51CrossRefPubMedCentralPubMedGoogle Scholar
  15. 15.
    Sugimori C, Mochizuki K, Qi Z et al (2009) Origin and fate of blood cells deficient in glycosylphosphatidylinositol anchored protein with bone marrow failure. Br J Haematol 147:102–112CrossRefPubMedGoogle Scholar
  16. 16.
    Madkaikar M, Gupta M, Jijina F, Ghosh K (2009) Paroxysmal nocturnal haemoglobinuria: diagnostic tests, advantages, & limitations. Eur J Haematol 83:503–511CrossRefPubMedGoogle Scholar

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2013

Authors and Affiliations

  1. 1.National Institute of Immunohaematology (ICMR), KEM HospitalMumbaiIndia

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