Chronic Neutrophilic Leukemia with V617F JAK2 Mutation

  • Smeeta Gajendra
  • Ritu Gupta
  • Meenal Chandgothia
  • Lalit Kumar
  • Richa Gupta
  • Snehal Motilal Chavan
Case Report


Chronic neutrophilic leukemia (CNL) is a rare disease grouped under World health organization classification as chronic myeloproliferative disease. It is a diagnosis of exclusion in patients with sustained mature neutrophilia and splenomegaly with no evidence of other myeloproliferative disease or reactive neutrophilia. V617F JAK 2 mutation has been described in classical myeloproliferative diseases, but its association with CNL has been reported in a few cases. Here in, we describe three cases of CNL with presence of V617F JAK 2 mutation. To distinguish CNL from secondary neutrophilia can be difficult. Detection of the V617F JAK 2 mutation in such scenario can provide a useful diagnostic test to establish the neoplastic nature of the neutrophilia.


Chronic myeloproliferative disease Chronic neutrophilic leukemia V617F JAK 2 mutation 


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Copyright information

© Indian Society of Haematology & Transfusion Medicine 2012

Authors and Affiliations

  • Smeeta Gajendra
    • 1
  • Ritu Gupta
    • 1
  • Meenal Chandgothia
    • 1
  • Lalit Kumar
    • 2
  • Richa Gupta
    • 1
  • Snehal Motilal Chavan
    • 3
  1. 1.Laboratory Oncology UnitDr. B.R.A IRCH, All India Institute of Medical Sciences (AIIMS)New DelhiIndia
  2. 2.Department of Medical OncologyDR. B.R.A IRCH, All India Institute of Medical Sciences (AIIMS)New DelhiIndia
  3. 3.Acton Biotech (I) Pvt. LtdPuneIndia

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