Transfusion-Related Acute Lung Injury

Case Report
  • 194 Downloads

Abstract

Transfusion-related acute lung injury (TRALI) is related to the transfusion of blood components. Typically, it is a clinical syndrome, characterized by the sudden onset of dyspnea, hypoxemia and bilateral non-cardiogenic pulmonary edema. A 83-year-old female patient with a history of AML developed TRALI after receiving 6 units of platelets. TRALI symptoms was started 10 min later the transfusion. AML is a risky group for TRALI. While giving transfusion to the risky groups of TRALI one must be more careful. The mortality rate caused by TRALI will decrease if the patient who is thought to have TRALI or who has bilateral pulmonary edema without any other reason showing the existance of TRALI is given ventilatory support at the right time.

Keywords

TRALI  Syndrome Ventilator 

References

  1. 1.
    Siliman C, Boshkov L, Mehdizadehkashi Z, Elzi D, Dickey W, Podlosky L, Clarke G, Ambruso D (2003) Transfusion-related acute lung injury: epidmiology and a prostpective analysis of etiologic factors. Blood 101:454–462CrossRefGoogle Scholar
  2. 2.
    Sokolovic M, Pastores SM (2010) Transfusion therapy and acute lung injury. Expert Rev Respir Med 4:387–393PubMedCrossRefGoogle Scholar
  3. 3.
    Goldman M, Weberet KE, Arnold DM, Freedman J, Hannon J, Blajchman MA (2005) Proceedings of a consensus conference: towards and understanding of TRALI. Transfus Med Rev 19:2–31PubMedCrossRefGoogle Scholar
  4. 4.
    Vlaar AP, Binnekade JM, Prins D, Van Stein D, Hofstra JJ, Schultz MJ, Juffermans NP (2010) Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case–control study. Crit Care Med 38:771–778PubMedCrossRefGoogle Scholar
  5. 5.
    Triulzi D (2009) Transfusion-related acute lung injury: current concepts for the clinician. Anesthe-Analg 108:770–776CrossRefGoogle Scholar
  6. 6.
    Propovsky MA, Abel MD, Moore SB (1983) Transfusion-related acute lung injury associated with passive transfer of antileukocyte antibodies. Am Rev Respir Dis 128:185–189Google Scholar
  7. 7.
    Propovsky MA, Chaplin HC, Moore SB (1992) Transfusion-related acute lung injury: a neglected, serious complication of homotherapy. Transfusion 32:589–592CrossRefGoogle Scholar
  8. 8.
    Yomtovian R, Kline W, Press C (1984) Severe pulmonary hypersensitivity associated with passive transfusion of a neutrophil-specific antibody. Lancet 1:244–246PubMedCrossRefGoogle Scholar
  9. 9.
    Baggiolini M, Walz A, Kunkel SL (1989) Neutrophil-activating peptide-1/interleukin 8, a novel cytokin that activates neutrophils. J Clin Investig 84:1045–1049PubMedCrossRefGoogle Scholar
  10. 10.
    Borish L, Rosenbaum R, Albury L, Clark S (1989) Activation of neutrophils by recombinant interleukin 6. Cell Immunol 121:280–289PubMedCrossRefGoogle Scholar
  11. 11.
    Sarkodee-Adoo CB, Kendall JM, Sridhara R, Lee EJ, Schiffer CA (1998) The relationship between the duration of platelet storage and the development of transfusion reactions. Transfusion 38:229–235PubMedCrossRefGoogle Scholar
  12. 12.
    Webert KE, Blajchman MA (2005) Transfusion-related acute lung injury. Curr Opin Hematol 12:480–487PubMedCrossRefGoogle Scholar

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2012

Authors and Affiliations

  • Hava Üsküdar Teke
    • 1
  • Orhan Behret
    • 1
  • Deniz Teke
    • 1
  1. 1.Department of Hematology, Anesthesiology, CardiologyKayseri Education and Research HospitalKayseriTurkey

Personalised recommendations