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Indian Journal of Hematology and Blood Transfusion

, Volume 28, Issue 3, pp 144–146 | Cite as

Physiological Changes in Hematological Parameters During Pregnancy

  • Surabhi Chandra
  • Anil Kumar TripathiEmail author
  • Sanjay Mishra
  • Mohammad Amzarul
  • Arvind Kumar Vaish
Review Article

Abstract

Pregnancy is a state characterized by many physiological hematological changes, which may appear to be pathological in the non-pregnant state. The review highlights most of these changes along with the scientific basis for the same, as per the current knowledge, with a special reference to the red blood and white blood cells, platelets and hemostatic profile.

Keywords

Pregnancy Physiological Hematological changes 

References

  1. 1.
    Ramsay Margaret (2010) Normal hematological changes during pregnancy and the puerperium. In: Pavord S, Hunt B (eds) The obstetric hematology manual. Cambridge University Press, Cambridge, pp 1–11Google Scholar
  2. 2.
    Bernstein IM, Ziegler W, Badger GJ (2001) Plasma volume expansion in early pregnancy. J Obstet Gynecol 97:669CrossRefGoogle Scholar
  3. 3.
    Bjorksten B, Soderstrom T, Damber M-G, von Schoultz B, Stigbrand T (1978) Polymorphonuclear leucocyte function during pregnancy. Scand J Immunol 8(3):257–262PubMedCrossRefGoogle Scholar
  4. 4.
    Ajzenberg N, Dreyfus M, Kaplan C, Yvart J, Weill B, Tchernia G (1998) Pregnancy-associated thrombocytopenia revisited: assessment and follow-up of 50 cases. Blood 92(12):4573–4580PubMedGoogle Scholar
  5. 5.
    Barriga C, Rodriguez AB, Orega E (1994) Increased phagocytic activity of polymorphonuclear leucocytes during pregnancy. Eur J Obstet Gynecol Reprod Biol 57(1):43–46PubMedCrossRefGoogle Scholar
  6. 6.
    Crocker IP, Baker PN, Fletcher J (2000) Neutrophil function in pregnancy and rheumatoid arthritis. Ann Rheumat Dis 59:555–564PubMedCrossRefGoogle Scholar
  7. 7.
    Taylor DJ, Lind T (1979) Red cell mass during and after normal pregnancy. Br J Obstet Gynecol 86:364–370CrossRefGoogle Scholar
  8. 8.
    Fleming AF (1975) Hematological changes in pregnancy. Clin Obstet Gynecol 2:269Google Scholar
  9. 9.
    Gatti L, Tinconi PM, Guarneri D, Bertuijessi C, Ossola MW, Bosco P, Gianotti G (1994) Hemostatic parameters and platelet activation by flow-cytometry in normal pregnancy: a longitudinal study. Internat J Clin Lab Res 24(4):217–219CrossRefGoogle Scholar
  10. 10.
    Konijnenberg A, Stokkers E, van der Post J (1997) Extensive platelet activation in preeclampsia compared with normal pregnancy: enhanced expression of cell adhesion molecules. Am J Obstet Gynecol 176(2):461–469PubMedCrossRefGoogle Scholar
  11. 11.
    Jessica M, Badger F, Hseih CC, Troisi R, Lagiou P, Polischman N (2007) Plasma volume expansion in pregnancy: implications for biomarkers in population studies. Cancer Epidemiol Biomarkers 16:1720CrossRefGoogle Scholar
  12. 12.
    Karalis L, Nadan S, Yemen EA (2005) Platelet activation in pregnancy induced hypertension. Thromb Res 116(5):377–383PubMedCrossRefGoogle Scholar
  13. 13.
    Kline AJ, Williams GW, Hernandez-Nino J (2005) D-Dimer concentration in normal pregnancy: new diagnostic thresholds are needed. Clin Chem 51(5):825–829PubMedCrossRefGoogle Scholar
  14. 14.
    Edlestam G, Lowbeer C, Kral G et al (2001) New reference values for routine blood samples and human neutrophilic lipocalin during third trimester pregnancy. Scand J Clin Lab Inv 61:583–592CrossRefGoogle Scholar
  15. 15.
    Shehlata N, Burrows RF, Kelton JG (1999) Gestational thrombocytopenia. Clin Obstet Gynecol 42:327–334CrossRefGoogle Scholar
  16. 16.
    de Boer K, ten Cate JW, Sturk A, Borm JJ, Treffers PE (1989) Enhanced thrombin generation in normal and hypertensive pregnancy. Am J Obstet Gynecol 160(1):95–100PubMedGoogle Scholar
  17. 17.
    Eichinger S (2004) D-dimer testing in pregnancy. Pathophysiol Hemost Thromb 33:327–329CrossRefGoogle Scholar
  18. 18.
    Clark P, Brennard J, Conkie JA et al (1998) Activated protein C sensitivity, protein C, protein S and coagulation in normal pregnancy. Thromb Hemost 79:1166–1170Google Scholar

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2012

Authors and Affiliations

  • Surabhi Chandra
    • 1
  • Anil Kumar Tripathi
    • 1
    Email author
  • Sanjay Mishra
    • 1
  • Mohammad Amzarul
    • 1
  • Arvind Kumar Vaish
    • 2
  1. 1.Department of Clinical Hematology and Medical OncologyCSM Medical UniversityLucknowIndia
  2. 2.Department of MedicineCSM Medical UniversityLucknowIndia

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