A Study of Plasma Fibrinogen Level in Type-2 Diabetes Mellitus and its Relation to Glycemic Control

  • Archana Sachin BembdeEmail author
Original Article


The high prevalence of classic cardiac risk factors in patients with type 2 diabetes mellitus does not explain the increased cardiovascular related morbidity and mortality in these patients. Fibrinogen may have a role in this excess risk. This study is undertaken to know the fibrinogen levels in type 2 diabetes mellitus and its relations to glycemic control. In the present study fibrinogen levels (Clauss method) were estimated in 100 type 2 diabetic subjects and 100 age and sex matched controls. Fibrinogen was correlated with various parameters like glycosylated hemoglobin (cation exchange resin method), age, sex, smoking, body mass index (kg/m2), hypertension and ischemic heart disease. Higher plasma fibrinogen levels were found in type 2 diabetes mellitus patients (656 ± 130 mg/dl) as compared to controls (324 ± 139 mg/dl) which were statistically significant. Fibrinogen levels were associated with age (P < 0.01), hypertension (P < 0.01), body mass index (P < 0.01), smoking (P < 0.01), ischemic heart disease (P < 0.01), and glycosylated hemoglobin (r = 0.49) in diabetics in a significant manner. But no correlation was found with sex (P < 0.05) in diabetes. In controls, association was found between fibrinogen levels and smoking (P < 0.01) and body mass index (P < 0.01). Patients with type 2 diabetes mellitus had a high prevalence of hyperfibrinogenemia. Fibrinogen levels were independently associated with hemoglobin A1c values, which suggests that fibrinogen may be involved in the increased cardiovascular risk of patients with type 2 diabetes mellitus.


Type 2 diabetes mellitus Fibrinogen Glycosylated hemoglobin 



The study was carried out with the permission granted from the Institute BLDEA’s Shri B.M Patil Medical College, Bijapur, Karnataka.


  1. 1.
    Alvin CP (2001). Diabetes Mellitus. In: Braunwald E, Faucei AS, Kasper DL, Hauser SL, Longo DL, Larry JJ (eds) Harrison’s principles of internal medicine, 15th edn. McGraw Hill Medical Publishing division, New York, pp 2109–2137Google Scholar
  2. 2.
    Bruno G, Cavallo-perin P, Bargero G, Borra M, Errico ND, Pagano G (1996) Association of fibrinogen with glycemic control and albumin excretion rate in patients with non-Insulin-dependent diabetes mellitus. Ann Intern Med 125:653–657PubMedGoogle Scholar
  3. 3.
    Fuller JH, Keen H, Jarrett RJ, Omer T, Meade TW, Charkrabarti R (1979) Haemostatic variables associated with diabetes and its complications. Br Med J 2:964–966PubMedCrossRefGoogle Scholar
  4. 4.
    Kannel BW, Wilson WF, Belanger AJ, Gagnon Dr, D’Agostino BD (1987) Diabetes, fibrinogen, and risk of cardiovascular disease: the Framingham experience. JAMA 258:1183–1186PubMedCrossRefGoogle Scholar
  5. 5.
    Anjula J, Gupta HL, Narayan S (2001) Hyperfibrinogenemia in patients of diabetes mellitus in relation to glycemic control and urinary albumin excretion rate. JAPI 49:227–230Google Scholar
  6. 6.
    Ernst E, Ludwig KR (1993) Fibrinogen as a cardiovascular risk factor: a meta-analysis and review of literature. Ann Intern Med 118:956–963PubMedGoogle Scholar
  7. 7.
    Wilhelmsen L, Suardsudd K, Kristoffer KB, Larson B, Lennart W, Jibblin G (1984) Fibrinogen as a risk factor for stroke and myocardial infraction. N Engl J Med 311:501–505PubMedCrossRefGoogle Scholar
  8. 8.
    Thompson WD, Smith EB (1989) Atherosclerosis and coagulation system. J Pathol 159:97–106PubMedCrossRefGoogle Scholar
  9. 9.
    Mittal S, Ashutosh DwivediRN, Lalchandani A, Puri A, Mishra P et al (2002) Correlation of fibrinogen as an indicator of both long and short term glycemic control in diabetes. JAPI 50:129–130Google Scholar
  10. 10.
    Mohan A, Srinivasan V, Deepa R, Mohan V (2001) Lipoprotein(a): role in diabetes and its vascular complications. JAPI 49:1100–1105PubMedGoogle Scholar
  11. 11.
    Brownlee M, Ulassara H, Cerami A (1983) Nonenzymatic glycosylation reduces the susceptibility of fibrin to degradation by plasmin. Diabetes 32:680–684PubMedCrossRefGoogle Scholar
  12. 12.
    Pierpaola DF, Margaret GG, Haymond MW (1991) Differential effects of insulin deficiency on albumin and fibrinogen synthesis in humans. J Clin Invest 88:833–840CrossRefGoogle Scholar

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2011

Authors and Affiliations

  1. 1.BLDEA Medical CollegeBijapurIndia
  2. 2.MGM Medical CollegeAurangabadIndia
  3. 3.AurangabadIndia

Personalised recommendations