Childhood Tuberculosis Presenting with Haemophagocytic Syndrome
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Haemophagocytic syndrome is a life threatening complication of systemic infection resulting from an exaggerated immune response to a triggering agent. Prompt recognition and treatment of this disorder can abrogate otherwise high fatality associated with this disorder. A 2 year old girl presented with acute enteritis, developed prolonged fever and organomegaly complicated by multi-organ failure. She fulfilled the diagnostic criteria for haemophagocytic lymphohistiocytosis including bone marrow evidence of haemophagocytosis. In addition she had serological evidence of tubercular infection as well as a positive family history of tuberculosis. She responded rapidly to immunosuppressive therapy and anti-tubercular therapy. Our case illustrates the association of haemophagocytic syndrome with tuberculosis as well as the favourable response obtained with prompt diagnosis and treatment.
KeywordsVisceral Leishmaniasis Leishmaniasis Macrophage Activation Syndrome Childhood Tuberculosis High Grade Fever
The authors acknowledge the efforts of the nursing and laboratory staff in ensuring a successful outcome of the case.
Conflict of interest
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