Indian Journal of Hematology and Blood Transfusion

, Volume 27, Issue 3, pp 127–130 | Cite as

Evaluation of Platelets as Predictive Parameters in Dengue Fever

  • K. JayashreeEmail author
  • G. C. Manasa
  • P. Pallavi
  • G. V. Manjunath
Original Article


Dengue is an arboviral disease and occurs in tropical countries where over 2.5 billion people are at risk of infection. Each year an estimated 100 million cases of dengue fever (DF) occur and between 2.5 and 5 lakh cases of dengue hemorrhagic fever (DHF) are reported to WHO. Severe thrombocytopenia and increased vascular permeability are two major characteristics of DHF. A study was conducted to note the relationship between the platelet counts and severity of the disease in pediatric cases of dengue fever. Platelet counts were found to be predictive as well as recovery parameter of DF/DHF/DSS.


Dengue Dengue haemorrhagic syndrome  Dengue shock syndrome Platelet count Thrombocytopenia 


  1. 1.
    Chen RF, Yang KD, Wang L, Liu JW, Chiu CC, Cheng JT (2007) Different clinical and laboratory manifestations between dengue haemorrhagic fever and dengue fever with bleeding tendency. Trans R Soc Trop Med Hyg 101(11):1106–1113PubMedCrossRefGoogle Scholar
  2. 2.
    de Castro RA, de Castro JA, Barez MY, Frias MV, Dixit J, Genereux M (2007) Thrombocytopenia associated with dengue hemorrhagic fever responds to intravenous administration of anti-D (Rh(o)-D) immune globulin. Am J Trop Med Hyg 76(4):737–742PubMedGoogle Scholar
  3. 3.
    Phuong CXT, Nhan NT, Kneen R, Thuy PTT, Thien CV, Nga NTT et al (2004) Clinical diagnosis and assessment of severity of confirmed dengue infections in vietnamese children: is the world health organization classification system helpful? Am J Trop Med Hyg 70(2):172–179PubMedGoogle Scholar
  4. 4.
    Gubler DJ, Clark GG 1996. Dengue/dengue hemorrhagic fever: the emergence of a global health problem. Emerg Infect Dis. 1(2). Available at
  5. 5.
    Chairulfatah A, Setiabudi D, Agoes R, Colebunders R (2003) Thrombocytopenia and platelet transfusions in dengue haemorrhagic fever and dengue shock syndrome. Dengue Bull 27:141–143Google Scholar
  6. 6.
    Harun SR (1990) Clinical aspects of dengue haemorrhagic fever in children. In: proceedings of the seminar and workshop on dengue haemorrhagic fever and its control, Jakarta, pp 62–68Google Scholar
  7. 7.
    Samsi TK, Sugianto D (1990) Evaluation of concentrated platelet transfusion in severe dengue haemorrhagic fever. In: Proceedings of the National Conference of Indonesian Paediatrics Association, Ujung Pandang, pp 138–139Google Scholar
  8. 8.
    Saito M, Oishi K, Inoue S, Dimaano EM, Alera MT, Robles AM et al (2004) Association of increased platelet associated immunoglobulins with thrombocytopenia and the severity of disease in secondary dengue virus infections. Clin Exp Immunol 138:299–303PubMedCrossRefGoogle Scholar
  9. 9.
    World Health Organization (1997) Dengue haemorrhagic fever: diagnosis, treatment and control, 2nd edn. WHO, GenevaGoogle Scholar
  10. 10.
    Mourao MP, Lacerda MV, Macedo VO, Santo JB (2007) Thrombocytopenia in patients with dengue virus infection in Brazilian Amazon. Platelets 18(8):605–612PubMedCrossRefGoogle Scholar
  11. 11.
    Srichaikul T, Nimmannitya S (2000) Haematology in dengue and dengue hemorrhagic fever. Bailieres Best Pract Res Clin Haematol 13(2):261–276CrossRefGoogle Scholar
  12. 12.
    Nimmannitya S (1999) Dengue hemorrhagic fever: disorders of hemostasis. IX congress of the International Society of Haematology Asia-Pacific Division, Bangkok. pp.184–187.

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2011

Authors and Affiliations

  • K. Jayashree
    • 1
    Email author
  • G. C. Manasa
    • 1
  • P. Pallavi
    • 1
  • G. V. Manjunath
    • 1
  1. 1.Department of PathologyJSS Medical College and UniversityMysoreIndia

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