PRCA with myelofibrosis: an unusual case report

Case Report
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Abstract

The association of PRCA and myelofibrosis is very rare with only two such cases reported in the literature. Leukemic transformation in myelofibrosis is known but the progression of PRCA to acute leukemia is very rare. We present an unusual case of PRCA with myelofibrosis which after 14 months of transfusion dependent anemia transformed to acute monocytic leukemia.

Keywords

PRCA Myelofibrosis Acute Leukemia 
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References

  1. 1.
    Clement F (1979) Acquired chronic erythroblastopaenia followed by myelofibrosis. Remission with immunosuppressive therapy. Nouv Presse Med 8(46):3817–3820PubMedGoogle Scholar
  2. 2.
    Hatta Y, Kura Y, Yano T, Ushiyama H, Sugitani M, Okano T, et al (2005) Pure red cell aolasia and myelofibrosis in a B cell neoplasm. J Int Med Res 33(4):460–466PubMedGoogle Scholar
  3. 3.
    Cervantes F, Tassies D, Salgado C, Rovira M, Pereira A, Rozman C (1991) Acute transformation in nonleukemic chronic myeloproliferative disorders: actuarial probability and main characteristics in a series of 218 patients. Acta Haematol 85:124–127PubMedCrossRefGoogle Scholar
  4. 4.
    Mesa AR, Li CY, Ketterling RP, Schroeder GS, Knudson RA, and Tefferi A (2005) Leukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases. Blood 105(3):973–977PubMedCrossRefGoogle Scholar
  5. 5.
    Chikkappa G, Zarrabi MH, Tsan MF (1986) Pure red cell aplasia in patients with chronic lymphocytic leukemia. Medicine (Baltimore) 65(5):339–351CrossRefGoogle Scholar
  6. 6.
    Rose MG, Berliner N (2004) T-cell large granular lymphocyte leukemia and related disorders. The Oncologist 9(3):247–258PubMedCrossRefGoogle Scholar
  7. 7.
    Suvajdzic N, Marisavljevic D, Jovanovic V, Pantic M, Sefer D, Colovic M (1999) Pure red cell aplasia evolving through the hyperfibrotic myelodysplastic syndrome to the acute myeloid leukemia: some pathogenetic aspects. Hematology and cell therapy 41(1):27–29PubMedCrossRefGoogle Scholar
  8. 8.
    Pullarkat V, Bass RD, Gong JZ, Feinstein DI, Brynes RK (2003) Primary autoimmune myelofibrosis: Definition of a distinct clinicopathologic syndrome. Am J Haematol 72:8–12CrossRefGoogle Scholar
  9. 9.
    Rondeau E, Solal-Celigny P, Dhermy D, Vroclaus V, Brousse N, Beruarde et al (1983) Immune disorders in agnogenic myeloid metaplasia:relations to myelofibrosis. Br J Haematol 53:467–475PubMedCrossRefGoogle Scholar
  10. 10.
    Gordon BR, Colman M, Kohen P et al (1981) Immunologic abnormalities in myelofibrosis with activation of the complement system: Blood 58:904–910PubMedGoogle Scholar

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2008

Authors and Affiliations

  • Rakhee Kar
    • 1
  • Manoranjan Mahapatra
    • 1
  • Hara P. Pati
    • 1
  1. 1.Department of HematologyAIIMSNew DelhiIndia

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