Chronic eosinophilic leukemia: a case report and review of literature

  • Ashutosh Kumar
  • Swasti Sinha
  • Anil Kumar Tripathi
Case Report


Chronic Eosinophilic Leukemia (CEL) is a rare type of chronic myeloproliferative disorder of unknown etiology with no available true incidence. The vaguely overlapping clinico — pathological picture of CEL with idiopathic hypereosinophilic syndrome (IHES) often adds to the diagnostic confusion. An evidence of genetic clonality of eosinophils or an increase in blast cells in the blood or bone marrow is mandatory for diagnosis of CEL while no specific diagnostic tests exist for IHES; making it an entity of exclusion. Till date, CEL is a rarely reported entity in India. We add yet another case of eosinophilic leukemia along with review of available literature.


Chronic eosinophilic leukemia Idiopathic Hypereosinophilic syndrome 


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  1. 1.
    Vardiman JW et al (2001) Chronic myeloproliferative diseases and Myelodysplastic / myeloproliferative diseases. World Health Organization Classificationof Tumours. Pathology and Genetics. Tumours of Haematopoietic and Lymphoid Tumours. H. N. Jaffe ES, Stein H, Vardiman JW. Lyon, France, IARC Press: 17–31, 47–52Google Scholar
  2. 2.
    Bently HP Jr, Reardon AE, and Knoedler JP (1961) Eosinophilic leukemia. American Journal of Medicine 30:310–322CrossRefGoogle Scholar
  3. 3.
    Odeberg B (1965) Eosinophilic leukemia and disseminated eosinophilic collagen disease-a disease entity? Acta Medica Scandinavica 177:129–144PubMedCrossRefGoogle Scholar
  4. 4.
    Bengtsson E (1968) Eosinophilic leukemia-an immunopathological reaction? Acta Paediatrica Scandinavica 57: 245–249PubMedCrossRefGoogle Scholar
  5. 5.
    Benvenisti DS, and Ultmann JE (1969) Eosinophilic leukemia. Report of five cases and review of literature. Annals of Internal Medicine 71:731–745PubMedGoogle Scholar
  6. 6.
    Flannery EP, Dillon DE, Freeman MVR, Levy JD, d’Ambrosio U and Bedynek JL (1972) Eosinophilic leukemia with fibrosing endocarditis and short Y chromosome. Annals of Internal Medicine 77:223–228PubMedGoogle Scholar
  7. 7.
    Zucker-Franklin D (1974) Eosinophil function and disorders. Advances in Internal Medicine 19:1–25PubMedGoogle Scholar
  8. 8.
    Chusid MJ, Dale DC, West BC and Wolff SM (1975) The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine(Baltimore) 54:1–27Google Scholar
  9. 9.
    Rudolf WHR, Yasemien M, Martin W, Ulrich K, Ulf S, Christian G, and Klaus H (1997) Chronic eosinophilic leukemia (CEL): a distinct myeloproliferative disease. British Journal of Haematology 96:117–123CrossRefGoogle Scholar
  10. 10.
    Oliver JWDI, Morgan DL, Tonk VS (1998) Chronic eosinophilic leukemia and hypereosinophilic syndromes. proposal for classification, literature review, and report of a case with a unique chromosomal abnormality. Cancer genet Cytogenet 107(2):111–117PubMedCrossRefGoogle Scholar
  11. 11.
    Ma SK, K Y, Shek TW, Wan TS, Chow EY, Chan JC, Chan LC (1999) The role of trisomy 8 in the pathogenesis of chronic eosinophilic leukemia. Hum Pathol 30(7): 864–868PubMedCrossRefGoogle Scholar
  12. 12.
    Saitoh TSM, Inoue M, Ishizuka H, Kura Y, Yamazaki T, Itoh T, Sawada U, Horie T (2002) CD25 positive chronic eosinophilic leukemia with myelofibrosis.[Article in Japanese]. Rinsho Ketsueki 43(10):918–923PubMedGoogle Scholar
  13. 13.
    Lepretre SJF, Buchonnet G, Lenain P, Stamatoullas A, Kupfer I, Courville P, Callat MP, Contentin N, Bastard C, Tilly H (2002) Eosinophilic leukemia associated with t(2;5)(p23;q31). Cancer Genet Cytogenet 133(2):164–167PubMedCrossRefGoogle Scholar
  14. 14.
    Granjo ELM, Lopes JM, Doria S, Orfao A, Ying S, Barata LT, Miranda M, Cross NC, Bain BJ (2002) Chronic eosinophilic leukemia presenting with erythroderma, mild eosinophilia and hyper-Ig E: clinical, immunological and cytogenetic features and therapeutic approach. A case report. Acta Haematol 107(2):108–112CrossRefGoogle Scholar
  15. 15.
    Cools JDD, Gotlib J et al (2003) A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 348:1201–1214PubMedCrossRefGoogle Scholar
  16. 16.
    Shah AM, Jogelkar M (1987) Eosinophilic colitis as a complication of the hypereosinophilic syndrome. Postgrad Med J 63:485–487PubMedCrossRefGoogle Scholar
  17. 17.
    Syed Haider MF (2005) Hypereosinophilic Syndrome. Indian journal for practicing doctors 2 (No. 3)Google Scholar
  18. 18.
    Venkatesh CME, Janani S, Malathi S, Vijayakumar M, Nammalwar BR (2006) Hypereosinophilic syndrome. Indian J Pediatr 73:237–239PubMedCrossRefGoogle Scholar
  19. 19.
    Ayalew Tefferi MM et al (2006). Eosinophilia: secondary, clonal and idiopathic (review). British Journal of Haematology 133(5):468PubMedCrossRefGoogle Scholar
  20. 20.
    B Presentey, ZJ, Mintz U (1979) Eosinophilic leukaemia: Morphological, cytochemical, and electron microscopic studies. Journal of Clinical Pathology 32:261–271CrossRefGoogle Scholar

Copyright information

© Indian Society of Haematology & Transfusion Medicine 2007

Authors and Affiliations

  • Ashutosh Kumar
    • 1
  • Swasti Sinha
    • 1
  • Anil Kumar Tripathi
    • 2
  1. 1.Department of PathologyKing George’s Medical UniversityLucknowIndia
  2. 2.Department of MedicineKing George’s Medical UniversityLucknowIndia

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