The Japanese Breast Cancer Society Clinical Practice Guideline for radiation treatment of breast cancer, 2018 edition

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The Japanese Breast Cancer Society (JBCS) Clinical Practice Guideline was revised in 2018. This article describes the revise points in the section on radiation therapy (RT).

Methods and materials

The JBCS formed task force to update the JBCS Clinical Practice Guideline 2015 edition. Background questions (BQs) deal with standard treatments of breast cancer in clinical practice. Clinical questions (CQs) highlight the important treatments in which controversy remains. The task force for RT section addressed the 10 BQs, the 10 CQs, and the 4 Future reseach questions (FQs). For each CQ, systematic literature reviews and meta-analyses were conducted, and recommendations, strength of recommendation and strength of evidence were determined according to the protocol in Morizane et al. (Minds Handbook for Clinical Practice Guideline Development, 2014).


The recommendations, the strength of recommendation and the strength of evidence were determined based on the systematic literature reviews and the meta-analyses for each CQ.


The JBCS updated the Clinical Practice Guideline. RT represents a significant portion of the breast cancer treatment, and these recommendations regarding RT will be useful in individualized, shared decision making between physicians and patients.

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We would like to acknowledge the contributions of all member of The Japanese Breast Cancer Society Clinical Practice Guidelines Committee, all members of the systematic reviewer, Fujimi Kawai and Shinichi Abe of Japan Medical Library Association, Prof. Masahiro Yoshida of International University of Health and Welfare, and Kanehara Publishing Co., Ltd.,Hitomi Sasaki and Kazuyo Uno.

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Correspondence to Chikako Yamauchi.

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Conflict of interest

Chikako Yamauchi, Michio Yoshimura, Kenji Sekiguchi, Yasushi Hamamoto, Naomi Nakajima, Naoko Sanuki, Etsuyo Ogo, and Masahiko Oguchi have no conflict of interest. Hiroji Iwata reports grants and personal fees from Chugai, personal fees from AstraZeneca, personal fees from Daiichi Sankyo, grants and personal fees from Novartis, grants from MSD, grants and personal fees from Lilly, personal fees from Kyowa Hakko Kirin, personal fees from Pfizer, during the conduct of the study. However, Dr. Iwata confirms that the total fee from each company is not over the limited fee determined by JBCS. Shigehira Saji reports grants and personal fees (honoraria for lectures) from Eisai, grants and personal fees from Chugai, grants and personal fees from Astra Zeneca, grants and personal fees from Takeda, grants and personal fees from Novartis, grants and personal fees from Taiho, personal fees from Kyowahakko Kirin, personal fees from Pfizer, personal fees from Daiichi Sankyo, grants and personal fees from Nihon Kayaku, grants from Ono, outside the submitted work; Dr. Saji is executive board member of JBCRG and JBCS.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Yamauchi, C., Yoshimura, M., Sekiguchi, K. et al. The Japanese Breast Cancer Society Clinical Practice Guideline for radiation treatment of breast cancer, 2018 edition. Breast Cancer 27, 9–16 (2020) doi:10.1007/s12282-019-01019-5

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