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Breast Cancer

, Volume 27, Issue 1, pp 70–76 | Cite as

Breast reconstruction after risk-reducing mastectomy in BRCA mutation carriers

  • Naomi Nagura
  • Naoki Hayashi
  • Junko Takei
  • Atsushi Yoshida
  • Tomohiro Ochi
  • Yoshiko Iwahira
  • Hideko YamauchiEmail author
Original Article
  • 131 Downloads

Abstract

Background

Breast reconstruction is a favorable option for women with BRCA1 or BRCA2 mutations (BRCA1/2Mut+) who undergo risk-reducing mastectomy (RRM). We assessed characteristics of patients who underwent RRM, with or without breast reconstruction.

Methods

We included 46 patients with BRCA1/2Mut+ who underwent RRM from July 2011 to December 2017.

Results

Among the 46 patients who underwent RRM, 3 had not been diagnosed with breast cancer (BC) and 43 had cancer in a single breast; 33 patients (71.7%) underwent breast reconstruction with RRM; and 13 patients (28.3%) did not undergo breast reconstruction. All of 3 patients who had not been diagnosed with BC underwent bilateral RRM with breast reconstruction. There was no significant difference of clinical characteristic between patients undergoing RRM with and without breast reconstruction. However, patients who decided to undergo RRM with the current diagnosis of BC had significantly higher rates of RRM with breast reconstruction than that of patients with a past history of BC (P = 0.043). The rate of nipple-sparing mastectomy (NSM) in patients with breast reconstruction was significantly higher (28 of the 37 breasts, 75.7%) than that in patients without reconstruction (3 of the 14 breasts, 21.4%) (P < 0.001). Two patients who had complications underwent RRM with breast reconstruction, and one of them had a history of irradiation after lumpectomy.

Conclusions

For BRCA1/2Mut+ patients, the decision of taking RRM with the diagnosis of current BC might affect whether they undergo immediate breast reconstruction with RRM. These patients who undergo RRM with breast reconstruction preferred NSM to skin-sparing mastectomies.

Keywords

BRCA mutation carriers Risk-reducing mastectomy Breast cancer Breast reconstruction 

Notes

Acknowledgements

We would like to express our gratitude to all the colleagues and staff at St. Luke’s International Hospital and the Breast Surgery Clinic.

Funding

Funding has been received from Health, Labour and Welfare in Japan with Grand No. Health, Labour and Welfare Sciences Research Grants (H29-policy for cancer-general-003) and (18cm0106503h0003). The fee for the risk reduction procedure was paid by the patient own.

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Copyright information

© The Japanese Breast Cancer Society 2019

Authors and Affiliations

  1. 1.Department of Breast Surgical OncologySt. Luke’S International HospitalTokyoJapan
  2. 2.Breast Surgery Clinic, YCC Takanawa Bild.TokyoJapan

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