Breast Cancer

, Volume 24, Issue 3, pp 345–352 | Cite as

Fulvestrant plus targeted agents versus fulvestrant alone for treatment of hormone-receptor positive advanced breast cancer progressed on previous endocrine therapy: a meta-analysis of randomized controlled trials

  • Wen-Zhao Lin
  • Qi-Ni Xu
  • Hong-Biao Wang
  • Xu-Yuan Li
Review Article

Abstract

To compare the addition of targeted agents to fulvestrant with fulvestrant alone in hormone-receptor positive advanced breast cancer progressed on previous endocrine therapy; a meta-analysis of all relevant randomized controlled trials was performed. The PubMed, Embase databases and the Cochrane Central Register of Controlled Trials were searched for relevant publications reporting randomized controlled trials between January 2000 and June 2016. Progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and toxicity were assessed. Eight trials with a total of 2,470 patients were included in this meta-analysis. Compared with fulvestrant alone, combination therapy improved PFS (HR = 0.79; 95% CI 0.72–0.87; P = 0.00), increased ORR (RR = 1.70; 95% CI 1.30–2.21; P = 0.00), and showed a trend of increase in DCR (RR = 1.27; 95% CI 0.96–1.69, P = 0.09). In network analysis, only CD4/6 and PI3K/m-TOR inhibitors showed significant treatment effects with a P-score of 0.9999 and 0.7615, respectively. Patients treated with combination therapy developed more grade 3 or greater toxic effects (RR = 1.24; 95% CI 1.13–1.36; P = 0.00). Combining targeted agents with fulvestrant showed benefit but with increased toxicity in patients with advanced breast cancer compared with fulvestrant alone. Biomarkers for treatment optimization are lacking. The CD4/6 and PI3K/m-TOR pathways merit further investigation.

Keywords

Breast cancer Fulvestrant Targeted therapy Meta-analysis 

Notes

Compliance with ethical standards

Conflict of interest

The authors declared no potential conflicts of interest.

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Copyright information

© The Japanese Breast Cancer Society 2017

Authors and Affiliations

  • Wen-Zhao Lin
    • 1
  • Qi-Ni Xu
    • 2
  • Hong-Biao Wang
    • 2
  • Xu-Yuan Li
    • 1
  1. 1.Department of Medical OncologyShantou Central HospitalShantouChina
  2. 2.Department of Respiratory Medical OncologyCancer Hospital of Shantou University Medical CollegeShantouChina

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