Breast Cancer

, Volume 24, Issue 2, pp 180–190

DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention

  • Swetlana Gautam
  • Subhadeep Roy
  • Mohd Nazam Ansari
  • Abdulaziz S. Saeedan
  • Shubhini A. Saraf
  • Gaurav Kaithwas
Review Article


Cancer is a leading cause of death and major health concern worldwide. The animal and human studies support the presumption that inflammation directs the cancer initiation and progression. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) are the key players in the inflammatory cascade contributing towards the angiogenesis, tumor cell invasiveness, and disruption in the pathways of cellular proliferation/apoptosis. Contemporary studies have particularized a promising role of COX-2 and 5-LOX inhibitors in cancer chemoprevention. The present review is a pursuit to define implications of dual COX-2 and 5-LOX (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention.


Angiogenesis Apoptosis Cyclooxygenase Lipoxygenase NSAIDs Proliferation 



Adenosine triphosphate


Arachidonic acid


B cell chronic lymphocytic leukaemia-2




Extracellular signal regulated kinase


Guanosine diphosphate


Guanosine triphosphate


Hydroeicosa-tetraenoic acid


Hydroperoxyeicosa-tetraenoic acid








Mitogen activated protein kinase


Non-steroidal anti-inflammatory drugs


Nuclear factor-kappa B


Peroxisome proliferator activated receptor


Phosphoinositide-3 kinase/AKT


Phospholipase A2


Phosphatidylinositol 4, 5-bisphosphate




Polyunsaturated fatty acids


Protein kinase C






Receptor tyrosine kinase


Retinoid X receptor




Vascular endothelial growth factor


5-Hydroxytetraenoic acid


5-LOX activating protein


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Copyright information

© The Japanese Breast Cancer Society 2016

Authors and Affiliations

  • Swetlana Gautam
    • 1
  • Subhadeep Roy
    • 1
  • Mohd Nazam Ansari
    • 2
  • Abdulaziz S. Saeedan
    • 2
  • Shubhini A. Saraf
    • 1
  • Gaurav Kaithwas
    • 1
  1. 1.Department of Pharmaceutical Sciences, School of Biosciences and BiotechnologyBabasaheb Bhimrao Ambedkar University (A Central University)LucknowIndia
  2. 2.Department of Pharmacology, College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjKingdom of Saudi Arabia

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