Breast Cancer

, Volume 23, Issue 3, pp 367–377 | Cite as

The Japanese Breast Cancer Society clinical practice guideline for surgical treatment of breast cancer, 2015 edition

  • Hiromitsu JinnoEmail author
  • Masafumi Inokuchi
  • Toshikazu Ito
  • Kaoru Kitamura
  • Goro Kutomi
  • Takehiko Sakai
  • Yuko Kijima
  • Noriaki Wada
  • Yoshinori Ito
  • Hirofumi Mukai
Special Feature Japanese Breast Cancer Society Guidelines 2015


In the Clinical Practice Guideline for Surgical Treatment of Breast Cancer, clinical questions (CQs) were divided into 6 categories: (1) breast-conserving therapy (BCT); (2) axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB); (3) less invasive treatments (endoscopic surgery and non-surgical ablation); (4) breast reconstruction; (5) surgical treatment for advanced and metastatic breast cancer; and (6) others.

Major revisions to the 2015 edition were as follows: positive surgical margins for breast-conserving surgery were defined as ink on invasive or in situ cancer in CQ3; SLNB using indocyanine green (ICG) fluorescence imaging was newly described in CQ10; and recommendations were updated for CQ18 and 28.

Breast-conserving therapy

BCT refers to breast-conserving surgery (BCS), followed by radiation therapy (RT) to eradicate any microscopic residual disease. From 1972 to 1989, 6 randomized, controlled trials (RCTs) comparing BCT with mastectomy were...


Breast Cancer Brain Metastasis Sentinel Lymph Node Biopsy Lymphedema Axillary Lymph Node Dissection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Compliance with ethical standards

Conflict of interest

Yoshinori Ito received lecture fees from Chugai, Esai, and Novartis and research grants from Novartis, Chugai, Parexel, Esai, Sanofi, Taiho, EPS, Dai-ichi-sankyo, and Boehringer-ingelheim. The other authors declared no potential conflicts of interest.


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Copyright information

© The Japanese Breast Cancer Society 2016

Authors and Affiliations

  • Hiromitsu Jinno
    • 1
    Email author
  • Masafumi Inokuchi
    • 2
  • Toshikazu Ito
    • 3
  • Kaoru Kitamura
    • 4
  • Goro Kutomi
    • 5
  • Takehiko Sakai
    • 6
  • Yuko Kijima
    • 7
  • Noriaki Wada
    • 8
  • Yoshinori Ito
    • 9
  • Hirofumi Mukai
    • 8
  1. 1.Department of SurgeryTeikyo University School of MedicineTokyoJapan
  2. 2.Department of Breast OncologyKanazawa University HospitalIshikawaJapan
  3. 3.Department of SurgeryRinku General Medical CenterOsakaJapan
  4. 4.Department of Breast SurgeryNagumo Clinic FukuokaFukuokaJapan
  5. 5.Department of Surgery, Surgical Oncology and ScienceSapporo Medical University Hospital HokkaidoSapporoJapan
  6. 6.Breast Oncology CenterCancer Institute Hospital of the Japanese Foundation for Cancer ResearchTokyoJapan
  7. 7.Department of Digestive Surgery, Breast and Thyroid SurgeryKagoshima University School of MedicineKagoshimaJapan
  8. 8.Department of General and Breast SurgeryTokyo Dental College Ichikawa General HospitalChibaJapan
  9. 9.Department of Breast Medical OncologyThe Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyoJapan

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