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Breast Cancer

, Volume 23, Issue 4, pp 552–560 | Cite as

Local recurrence following treatment for breast cancer with an endoscopic nipple-sparing mastectomy

  • Naomi Sakamoto
  • Eisuke Fukuma
  • Ko Teraoka
  • Kazuei Hoshi
Original Article

Abstract

Purpose

Endoscopic nipple-sparing mastectomy (E-NSM) has been reportedly associated with smaller scars and greater patient satisfaction; however, long-term results of this procedure have not been made. The purpose of this retrospective study was to investigate the local recurrence (LR) rate and factors associated with it after E-NSM and to examine the oncologic safety of this procedure.

Methods

We reviewed the medical records of a total of 421 breasts in 404 patients who underwent E-NSM to investigate the LR rate and the factors associated with it. The clinico-pathological features and the treatment and outcomes of the patients with LRs were also examined.

Results

Eleven breasts (2.6 %) in 11 patients presented with LR as the first site of recurrence after a median follow-up time of 61 months. Among the 11 LRs, 9 patients presented with LR only, 1 patient exhibited regional lymph node recurrence, and 1 patient exhibited distant metastasis. The median time from surgery until LR was 25 months. Eight LRs developed near the original tumor site. The risk factors for LR in a multivariate analysis were a younger age of less than 40 years (p = 0.02), Stage III tumor (p = 0.01), and an inadequate surgical margin (p = 0.001). After the treatment, 6 patients had no evidence of disease, 2 patients died from metastatic disease, 2 patients experienced repeat LR, and the remaining patient who rejected excision exhibited a persistent LR.

Conclusions

E-NSM is an oncologically safe procedure and an acceptable method in selected patients requiring a mastectomy.

Keywords

Local recurrence Endoscopic surgery Nipple-sparing mastectomy Breast cancer recurrence Nipple involvement 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© The Japanese Breast Cancer Society 2015

Authors and Affiliations

  • Naomi Sakamoto
    • 1
  • Eisuke Fukuma
    • 1
  • Ko Teraoka
    • 1
  • Kazuei Hoshi
    • 2
  1. 1.Breast CenterKameda Medical CenterKamogawaJapan
  2. 2.Department of PathologyKameda Medical CenterKamogawaJapan

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