Breast Cancer

, Volume 22, Issue 4, pp 432–436 | Cite as

HER-2 positive primary solid neuroendocrine carcinoma of the breast: a case report and review of the literature

  • Guler Yavas
  • Pinar Karabagli
  • Murat Araz
  • Cagdas Yavas
  • Ozlem Ata
Case Report


Primary pure neuroendocrine carcinoma of the breast is an extremely rare tumor. We report a case of primary solid neuroendocrine carcinoma in a 77-year-old postmenopausal woman who was admitted to the hospital with masses on her right breast and axillary region. Radical mastectomy with axillary lymph node resection was performed. Immunohistochemical stainings of the tumor cells with synaptophysin, GCDFP-15, estrogen, progesterone, and c-erbB-2 were positive. Five of 16 lymph nodes were metastatic. She did not receive adjuvant chemotherapy. After 15 months of follow-up she is free of the disease. Literature review revealed that this is the second case of HER-2 positive primary neuroendocrine tumor of the breast.


Breast Carcinoma c-erbB-2 Neuroendocrine Tumor 


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Copyright information

© The Japanese Breast Cancer Society 2012

Authors and Affiliations

  • Guler Yavas
    • 1
  • Pinar Karabagli
    • 2
  • Murat Araz
    • 3
  • Cagdas Yavas
    • 4
  • Ozlem Ata
    • 3
  1. 1.Department of Radiation Oncology, Selcuklu Faculty of MedicineSelcuk UniversityKonyaTurkey
  2. 2.Department of Pathology, Selcuklu Faculty of MedicineSelcuk UniversityKonyaTurkey
  3. 3.Department of Medical Oncology, Selcuklu Faculty of MedicineSelcuk UniversityKonyaTurkey
  4. 4.Department of Radiation OncologyKonya Training and Research HospitalKonyaTurkey

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