Advertisement

Breast Cancer

, Volume 21, Issue 2, pp 236–240 | Cite as

Primary amelanotic melanoma of the breast: combating a rare cancer

  • Ahitagni BiswasEmail author
  • Shikha Goyal
  • Ayushi Jain
  • Vaishali Suri
  • Sandeep Mathur
  • Pramod Kumar Julka
  • Goura Kishor Rath
Case Report

Abstract

Background

Malignant melanoma is the foremost cause of metastasis to the breast from extramammary solid neoplasm. However primary melanoma of the breast is a distinct rarity. Primary melanoma involves the skin and less commonly the glandular parenchyma of the breast.

Method

We herein describe a case of primary amelanotic melanoma of the breast parenchyma in a 32-year-old female managed with a combination of surgery, adjuvant radiotherapy and immunotherapy.

Conclusion

This case report aims to increase awareness of unusual neoplasms of the breast which might require a different surgical and adjuvant therapeutic approach.

Keywords

Primary melanoma Breast Metastasis 

Reference

  1. 1.
    Kurul S, Tas F, Buyukbabani N, Mudun A, Baykal C, Camlica H. Different manifestations of malignant melanoma in the breast: a report of 12 cases and a review of literature. Jpn J Clin Oncol. 2005;34:202–6.CrossRefGoogle Scholar
  2. 2.
    Alzaraa A, Sharma N. Primary cutaneous melanoma of the breast: a case report. Cases J. 2008;1:212.PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Roy S, Dhingra K, Mandal S, Khurana N. Unusual presentation of metastatic amelanotic melanoma of unknown primary origin as a solitary breast lump. Melanoma Res. 2008;18:447–50.PubMedCrossRefGoogle Scholar
  4. 4.
    Ruffolo EF, Koerner FC, Maluf HM. Metaplastic carcinoma of the breast with melanocytic differentiation. Mod Pathol. 1997;10:592–6.PubMedGoogle Scholar
  5. 5.
    Yen H, Florentine B, Kelly LK, Bu X, Crawford J, Martin SE. Fine needle aspiration of a metaplastic breast carcinoma with extensive melanocytic differentiation: a case report. Diagn Cytopathol. 2000;23:46–50.PubMedCrossRefGoogle Scholar
  6. 6.
    Nobukawa B, Fujii H, Hirai S, Kumasaka T, Shimizu H, Matsumoto T, et al. Breast carcinoma diverging to aberrant melanocytic differentiation: a case report with histopathologic and loss of heterozygosity analyses. Am J Surg Pathol. 1999;23:1280–7.PubMedCrossRefGoogle Scholar
  7. 7.
    Mitchell S, Lachica R, Randall MB, Beech DJ. Paget’s disease of the breast areola mimicking cutaneous melanoma. Breast J. 2006;12:233–6.PubMedCrossRefGoogle Scholar
  8. 8.
    Pizzichetta MA, Canzonieri V, Massarut S, Gloghini A, Trevisan G, Veronesi A, et al. Pigmented mammary Paget’s disease mimicking melanoma. Melanoma Res. 2004;14:S13–5.PubMedCrossRefGoogle Scholar
  9. 9.
    Williams SA, Ehlers RA, Hunt KK, Min Y, Kuerer HM, Singletary SE, et al. Metastases to breast from nonbreast solid neoplasms. Presentation and determinants of survival. Cancer. 2007;110:731–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Vaughan A, Dietz JR, Moley JF, De Benedetti MK, Aft RL, Gillanders WE, et al. Metastatic disease to the breast: the Washington University experience. World J Surg Oncol. 2007;5:74.PubMedCentralPubMedCrossRefGoogle Scholar
  11. 11.
    Ravdel L, Robinson WA, Lewis K, Gonzalez R. Metastatic melanoma in the breast: a report of 27 cases. J Surg Oncol. 2006;94:101–4.PubMedCrossRefGoogle Scholar
  12. 12.
    Ewing CA, Miller MJ, Chhieng D, Lin O. Nonepithelial malignancies mimicking primary carcinoma of the breast. Diagn Cytopathol. 2004;31:352–7.PubMedCrossRefGoogle Scholar
  13. 13.
    Hancock C, Allen BC, Herrera GA. HMB-45 detection in adenocarcinomas. Arch Pathol Lab Med. 1991;115(9):886–90.PubMedGoogle Scholar
  14. 14.
    Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW. Immunohistochemical characteristics of melanoma. J Cutan Pathol. 2008;35(5):433–44.PubMedCrossRefGoogle Scholar
  15. 15.
    Filie AC, Simsir A, Fetsch P, Abati A. Melanoma metastatic to the breast: utility of fine needle aspiration and immunohistochemistry. Acta Cytol. 2002;46:13–8.PubMedCrossRefGoogle Scholar
  16. 16.
    Govender D, Sabaratnam RM, Essa AS. Clear cell ‘sugar’ tumor of the breast: another extrapulmonary site and review of the literature. Am J Surg Pathol. 2002;26:670–5.PubMedCrossRefGoogle Scholar
  17. 17.
    Damiani S, Chiodera P, Guaragni M, Eusebi V. Mammary angiomyolipoma. Virchows Arch. 2002;440:551–2.PubMedCrossRefGoogle Scholar
  18. 18.
    Thompson JF, McCarthy WH, Bosch CM, O’Brien CJ, Quinn MJ, Paramaesvaran S, et al. Sentinel lymph node status as an indicator of the presence of metastatic melanoma in regional lymph nodes. Melanoma Res. 1995;5:255–60.PubMedCrossRefGoogle Scholar
  19. 19.
    Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK, et al. Technical details of intra-operative lymphatic mapping for early melanoma. Arch Surg. 1992;127:392–9.PubMedCrossRefGoogle Scholar
  20. 20.
    Calabro A, Singletary SE, Balch CM. Patterns of relapse in 1001 consecutive patients with melanoma nodal metastases. Arch Surg. 1989;124:1051–5.PubMedCrossRefGoogle Scholar
  21. 21.
    Lee RJ, Gibbs JF, Proulx GM, Kollmorgen DR, Jia C, Kraybill WG. Nodal basin recurrence following lymph node dissection for melanoma: implications for adjuvant radiotherapy. Int J Radiat Oncol Biol Phys. 2000;46:467–74.PubMedCrossRefGoogle Scholar
  22. 22.
    Sause WT, Cooper JS, Rush S, Ago CT, Cosmatos D, Couglin CT, et al. Fraction size in external beam radiotherapy in the treatment of melanoma. Int J Radiat Oncol Biol Phys. 1991;20:429–32.PubMedCrossRefGoogle Scholar
  23. 23.
    Kirkwood JM, Manola J, Ibrahim J, Sondak V, Ernstoff MS, Rao U, Eastern Cooperative Oncology Group. A pooled analysis of Eastern Cooperative Oncology Group and Intergroup trials of adjuvant high dose interferon for melanoma. Clin Cancer Res. 2004;10:1670–7.PubMedCrossRefGoogle Scholar

Copyright information

© The Japanese Breast Cancer Society 2010

Authors and Affiliations

  • Ahitagni Biswas
    • 1
    Email author
  • Shikha Goyal
    • 1
  • Ayushi Jain
    • 2
  • Vaishali Suri
    • 2
  • Sandeep Mathur
    • 2
  • Pramod Kumar Julka
    • 1
  • Goura Kishor Rath
    • 1
  1. 1.Department of Radiotherapy and OncologyAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of PathologyAll India Institute of Medical SciencesNew DelhiIndia

Personalised recommendations