Refractory lung metastasis from breast cancer treated with multidisciplinary therapy including an immunological approach
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- Takada, M., Terunuma, H., Deng, X. et al. Breast Cancer (2011) 18: 64. doi:10.1007/s12282-010-0198-5
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A suggestive case of metastatic disease from breast cancer is reported. The HER-2-positive tumor was refractory to several agents, including anti-HER-2 therapy, trastuzumab, and lapatinib. After re-induction of trastuzumab in combination with activated natural killer (NK) cell injection therapy, tumor markers decreased, and finally a synergistic effect of taxane and capecitabine led to treatment response. This case suggests that multidisciplinary therapy including an immunological approach might be a breakthrough in the treatment of refractory disease.