Breast Cancer

, Volume 17, Issue 4, pp 303–305 | Cite as

C-kit-positive gastric metastasis of lobular carcinoma of the breast masquerading as gastrointestinal stromal tumor

  • Bharathi Vennapusa
  • Sarah A. Oman
  • Gulshan Parasher
  • Lisa A. Cerilli
Case Report


A 61-year-old woman with no significant past history underwent gastric biopsies demonstrating a strongly c-kit-positive epithelioid malignancy, initially thought to represent gastrointestinal stromal tumor (GIST). Subsequent clinical and immunohistochemical evaluation proved the neoplasm to represent metastatic lobular carcinoma. This case illustrates that although c-kit is highly specific and sensitive for GIST, its expression may occur in a variety of other neoplasms, some of which morphologically resemble GIST and may present in the gastrointestinal tract as metastases. Therefore, a review of other c-kit-positive lesions is also highlighted.


Breast cancer Gastric metastasis C-kit Infiltrating lobular carcinoma Gastrointestinal stromal tumor (GIST) 


C-kit (c-kit protein, c-kit receptor)

C-kit proto-oncogene/CD117


Gastrointestinal stromal tumors


Gross cystic disease fluid protein




  1. 1.
    Nazareno J, Taves D, Preiksaitis HG. Metastatic breast cancer to the gastrointestinal tract: a case series and review of the literature. World J Gastroenterol. 2006;12(38):6219–24.PubMedGoogle Scholar
  2. 2.
    Taal BG, Peterse H, Boot H. Clinical presentation, endoscopic features, and treatment of gastric metastases from breast carcinoma. Cancer. 2000;89(11):2214–21.CrossRefPubMedGoogle Scholar
  3. 3.
    Miettnen M, Lasota J. KIT (CD117): A review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. App Immunohistochem Mol Morphol. 2005;13(3):205–20.CrossRefGoogle Scholar
  4. 4.
    Ulivi P, Zoli W, Medri L, Amadori D, Saragoni L, Barbanti F, et al. c-kit, SCF expression in normal, tumor breast tissue. Breast Cancer Res Treat. 2004;83(1):33–42.CrossRefPubMedGoogle Scholar
  5. 5.
    Modi S, Seidman AD, Dickler M, Moasser M, D’Andrea G, Moynahan ME, et al. A phase II trial of imatinib mesylate monotherapy in patients with metastatic breast cancer. Breast Cancer Res Treat. 2005;90(2):157–63.CrossRefPubMedGoogle Scholar

Copyright information

© The Japanese Breast Cancer Society 2009

Authors and Affiliations

  • Bharathi Vennapusa
    • 1
  • Sarah A. Oman
    • 1
  • Gulshan Parasher
    • 2
  • Lisa A. Cerilli
    • 1
  1. 1.Department of PathologyUniversity of New Mexico, MSC08 4640AlbuquerqueUSA
  2. 2.Division of Gastroenterology and Hepatology, Department of Internal MedicineUniversity of New Mexico, MSC08 4640AlbuquerqueUSA

Personalised recommendations