Breast Cancer

, 16:77

Indeterminate calcification and clustered cystic lesions are strongly predictive of the presence of mucocele-like tumor of the breast: a report of six cases

  • Koji Tanaka
  • Yoshifumi Komoike
  • Chiyomi Egawa
  • Kazuyoshi Motomura
  • Hiroki Koyama
  • Sachiko Nagumo
  • Tatsuki R. Kataoka
  • Hideo Inaji
Case Report

DOI: 10.1007/s12282-008-0058-8

Cite this article as:
Tanaka, K., Komoike, Y., Egawa, C. et al. Breast Cancer (2009) 16: 77. doi:10.1007/s12282-008-0058-8

Abstract

Mucocele-like tumor (MLT) of the breast is a mucinous disorder that is generally difficult to distinguish from mucinous carcinoma. Moreover, MLT is often accompanied by atypical ductal hyperplasia (ADH) or ductal carcinoma in situ (DCIS), and preoperative diagnosis is very confusing. In this paper, we summarize the clinicopathological characteristics of six cases of MLTs, comparing them with mucinous carcinoma. MLTs were characterized by clustered, coarse calcification on mammography and clustered, hypoechoic lesions with or without echogenic spots on ultrasonography. On fine-needle aspiration cytology (FNAC), three cases were correctly diagnosed and three cases were judged to be indeterminate, or insufficient material was present. Ultimately, excisional biopsies were performed to obtain a correct diagnosis in all cases. Immunohistochemical staining of MLTs accompanied by ADH or DCIS (malignant MLTs) revealed the presence of MUC6, while MLTs without ADH or DCIS (benign MLTs) were MUC6-negative. At present, as it is difficult to detect small areas of DCIS adjacent to the MLT by FNAC, excisional biopsy is essential. Immunohistochemical staining for MUC6 may be useful in differentiating between benign MLTs and malignant MLTs, although further investigation is needed.

Keywords

Mucocele-like tumor Mucinous carcinoma Breast cancer Immunohistochemical staining 

Abbreviations

MLT

Mucocele-like tumor

ADH

Atypical ductal hyperplasia

DCIS

Ductal carcinoma in situ

FNAC

Fine-needle aspiration cytology

MMG

Mammography

US

Ultrasonography

Copyright information

© The Japanese Breast Cancer Society 2008

Authors and Affiliations

  • Koji Tanaka
    • 1
  • Yoshifumi Komoike
    • 1
  • Chiyomi Egawa
    • 1
  • Kazuyoshi Motomura
    • 1
  • Hiroki Koyama
    • 1
  • Sachiko Nagumo
    • 2
  • Tatsuki R. Kataoka
    • 3
  • Hideo Inaji
    • 1
  1. 1.Department of Breast and Endocrine SurgeryOsaka Medical Center for Cancer and Cardiovascular Diseases, Osaka Prefectural Hospital OrganizationOsakaJapan
  2. 2.Department of CytologyOsaka Medical Center for Cancer and Cardiovascular Diseases, Osaka Prefectural Hospital OrganizationOsakaJapan
  3. 3.Department of PathologyOsaka Medical Center for Cancer and Cardiovascular Diseases, Osaka Prefectural Hospital OrganizationOsakaJapan

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