Updates on the Treatment of Non-Aspergillus Hyaline Mold Infections

  • Saman NematollahiEmail author
  • Shmuel Shoham
Current Management of Fungal Infections (S Jacobs, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Current Management of Fungal Infections


Purpose of Review

This review summarizes both the recent and relevant studies about the treatment of non-Aspergillus hyaline molds.

Recent Findings

Given the rarity of these infections, there have been no large randomized clinical trials regarding the most effective antifungal therapy.


Although there are more data for the treatment of Fusarium and Scedosporium, there are limited data with case reports that address the other rare hyalohyphomycetes. As we develop improved diagnostic techniques and larger fungal registries, we may be able to determine efficacious treatment modalities. We hope that future research will focus on implementing clinical trials with the new antifungals and ongoing development of novel fungal agents.


Hyaline molds Hyalohyphomycetes Emerging fungal infections Antifungal therapy Fusarium Scedosporium 


Compliance with Ethical Standards

Conflict of Interest

Shmuel Shoham reports grants from Merck, grants from Astellas, grants from Shire, grants from Scynexis, grants from F2G, grants from Cidara, grants from Gilead, personal fees from Jannssen, grants from Johnson and Johnson, and grants from Ansun outside the submitted work. Saman Nematollahi declare no conflicts of interest relevant to this manuscript.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Medicine, Division of Infectious DiseasesJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Transplant and Oncology Infectious Diseases ProgramJohns Hopkins University School of MedicineBaltimoreUSA

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