Current Fungal Infection Reports

, Volume 9, Issue 1, pp 6–14 | Cite as

Cerebral Fungal Infection in Pediatric Cancer Patients

  • Angela Haßler
  • Luciana Porto
  • Thomas Lehrnbecher
Pediatric Fungal Infections (T Lehrnbecher, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Pediatric Fungal Infections

Abstract

Invasive fungal disease (IFD) significantly contributes to morbidity and mortality in pediatric cancer patients, especially in those with acute leukemia and allogeneic hematopoietic stem cell transplantation. Cerebral fungal infections are a particular severe form of IFD, as they are difficult to diagnose and require aggressive treatment, and cure rates are still unacceptably low. Here, we review the current data on epidemiology, diagnosis, and the management of cerebral fungal infection in pediatric cancer patients and outline important questions which have to be addressed by further research.

Keywords

Invasive fungal infection Central nervous system Cancer Child Hematopoietic stem cell transplantation 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Angela Haßler and Luciana Porto have no disclosures. Thomas Lehrnbecher served in the speaker’s bureau of Astellas, Gilead Sciences, GlaxoSmithKline, Merck/MSD, and Pfizer; he also received a research grant from Gilead Sciences and is a consultant to Astellas, Gilead Sciences, and Merck/MSD.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Angela Haßler
    • 1
  • Luciana Porto
    • 2
  • Thomas Lehrnbecher
    • 1
  1. 1.Pediatric Hematology and OncologyHospital for Children and AdolescentsFrankfurtGermany
  2. 2.Neuroradiology DepartmentJohann Wolfgang Goethe-UniversityFrankfurtGermany

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