Current Fungal Infection Reports

, Volume 7, Issue 2, pp 152–159 | Cite as

Oral Colonization of Fungi

  • Julian R. Naglik
  • Shirley X. Tang
  • David L. Moyes
Translational Research (R Wheeler, Section Editor)

Abstract

Opportunistic microbes are able to exist as commensals or pathogens depending on local environmental conditions. The bacterial microbiome at mucosal sites (gut, oral and vaginal) has been well characterized but there has been less focus on the fungal component of the microbiome, the “mycobiome”, especially of the oral mucosa. Genomic characterization studies have shown that Candida species are the most prevalent fungal species in the mycobiomes of the murine gut and human oral cavity, with C. albicans being the most abundant fungal species in the oral cavity. In this review, we outline recent advances in the characterization of the oral mycobiome, how different Candida species colonize, invade and infect the oral cavity, and how epithelial surfaces play a key role in antifungal activity and discriminate between commensal and pathogenic Candida.

Keywords

Fungi Candida Yeast Hyphae Mycobiome Epithelium Mucosal Oral Vaginal Colonization Commensal Pathogen Infection Virulence Adhesion Invasion Damage Innate immunity Mitogen-activated protein kinase Nuclear factor-kappaB Signalling p38 c-Fos Danger response 

Notes

Conflict of Interest

J.R. Naglik, S.X. Tang and D.L. Moyes have received grants from the Medical Research Council and the Biotechnology and Biological Science Research Council

References

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Julian R. Naglik
    • 1
  • Shirley X. Tang
    • 1
  • David L. Moyes
    • 1
  1. 1.Department of Oral Immunology, Clinical and Diagnostic Science GroupKing’s College LondonLondonUK

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