The Role of Genetics in Host Responses to Mucosal and Invasive Candidiasis

Genomics and Pathogenesis (Shmuel Shoham, Section Editor)

DOI: 10.1007/s12281-011-0065-7

Cite this article as:
Shoham, S. & Dufresne, S.F. Curr Fungal Infect Rep (2011) 5: 262. doi:10.1007/s12281-011-0065-7

Abstract

The development of mucosal and invasive candidiasis depends upon a variety of innate and acquired risk factors. The number of genes known to be important for immunity against candidiasis has been increasing. Studies of variants of these genes are facilitating our knowledge of host predisposition to infection. Insights gleaned from genetic variants identified in patients with primary immunodeficiency syndromes such as chronic mucocutaneous candidiasis have further aided in this process. This article reviews data from genomic association studies in patients with such syndromes and in broader patient populations. These studies are placed within the framework of our current understanding of antifungal host defenses.

Keywords

Genomics Candida Host defenses Review Immunity Candidiasis Mucosal candidiasis Invasive candidiasis Recurrent vulvovaginal candidiasis RVVC Genes Genetics Genomic association studies Host responses Immunodeficiency Toll-like receptors Dectin-1 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Transplant and Oncology ID ProgramJohns Hopkins University School of MedicineBaltimoreUSA

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