Fungal Infections in Phagocytic Defects

Genomics and Pathogenesis (Shmuel Shoham, Section Editor)

DOI: 10.1007/s12281-011-0063-9

Cite this article as:
Freeman, A.F. & Holland, S.M. Curr Fungal Infect Rep (2011) 5: 245. doi:10.1007/s12281-011-0063-9

Abstract

Delineating the infection susceptibility of primary immunodeficiencies allows insight into host immunity. Filamentous mold infections are seen most frequently in chronic granulomatous disease, a neutrophil disorder characterized by impaired superoxide production. Mucocutaneous candidiasis occurs in disorders of impaired interleukin (IL)-17 and IL-22 signaling, such as seen in autosomal dominant hyper-IgE (Job’s) syndrome and in disorders with autoantibodies to these cytokines. The endemic dimorphic fungi are in part controlled by disorders of the IL-12/interferon (IFN)-γ pathway, such as IFN-γ receptor and STAT1 defects. Understanding the pathways involved in these primary immunodeficiency disorders will also provide insight into these infections in secondary immunodeficiencies and allow guidance for novel therapies.

Keywords

Fungal susceptibility Chronic granulomatous disease Hyper-IgE syndrome IL-17 IL-22 IL-12/IFN-gamma pathway Mold infections HIES Job syndrome Immunology Immunodeficiency Mucocutaneous candidiasis 

Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2011

Authors and Affiliations

  1. 1.Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of HealthBethesdaUSA

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