Recent Advances in the Detection of Neonatal Candidiasis
- 85 Downloads
Neonatal candidiasis is serious and often fatal. Blood culture, the standard for diagnosis, has a sensitivity of 50% or less, and isolate speciation and susceptibility takes several days. This review explores recent advances in Candida detection using various diagnostic strategies.
KeywordsDiagnosis Neonate Candida
Dr. Benjamin receives support from the United States Government for his work in pediatric and neonatal clinical pharmacology (1R01HD057956-02, 1R01FD003519-01, 1U10-HD45962-06, 1K24HD058735-01, and Government Contract HHSN267200700051C), the nonprofit organization Thrasher Research Foundation for his work in neonatal candidiasis (www.thrasherresearch.org), and from industry for neonatal and pediatric drug development (www.dcri.duke.edu/research/coi.jsp). Dr. Smith received support from NICHD 1K23HD060040-01.
Papers of particular interest, published recently, have been highlighted as: • Of importance
- 19.Shepard JR, Merz WG, Gherna M, et al.: Evaluation of yeast traffic light PNA FISH™ for detection of high prevalence Candida species. Poster presented at the 107th American Society for Microbiology General Meeting. Toronto, Canada; May 21–25, 2007.Google Scholar
- 24.• Oliveri S, Trovato L, Betta P, et al.: Experience with the Platelia Candida ELISA for the diagnosis of invasive candidosis in neonatal patients. Clin Microbiol Infect 2008, 14:391–393. This is one of the few recent studies on detection of neonatal candidiasis. While just a preliminary study, it suggests the possibility of mannan detection as a helpful tool in the diagnosis of candidemia in select neonates.CrossRefPubMedGoogle Scholar
- 37.• Zhao Y, Park S, Kreiswirth BN, et al.: Rapid real-time nucleic acid sequence-based amplification-molecular beacon platform to detect fungal and bacterial bloodstream infections. J Clin Microbiol 2009, 47:2067–2078. This article uses a known technology in a new way; it holds some promise in becoming a useful tool in the diagnosis of candidemia.CrossRefPubMedGoogle Scholar