The velvet repressed vidA gene plays a key role in governing development in Aspergillus nidulans

  • Min-Ju Kim
  • Won-Hee Jung
  • Ye-Eun Son
  • Jae-Hyuk Yu
  • Mi-Kyung Lee
  • Hee-Soo ParkEmail author


Fungal development is regulated by a variety of transcription factors in Aspergillus nidulans. Previous studies demonstrated that the NF-κB type velvet transcription factors regulate certain target genes that govern fungal differentiation and cellular metabolism. In this study, we characterize one of the VosA/VelB-inhibited developmental genes called vidA, which is predicted to encode a 581-amino acid protein with a C2H2 zinc finger domain at the C-terminus. Levels of vidA mRNA are high during the early and middle phases of asexual development and decrease during the late phase of asexual development and asexual spore (conidium) formation. Deletion of either vosA or velB results in increased vidA mRNA accumulation in conidia, suggesting that vidA transcript accumulation in conidia is repressed by VosA and VelB. Phenotypic analysis demonstrated that deletion of vidA causes decreased colony growth, reduced production of asexual spores, and abnormal formation of sexual fruiting bodies. In addition, the vidA deletion mutant conidia contain more trehalose and β-glucan than wild type. Overall, these results suggest that VidA is a putative transcription factor that plays a key role in governing proper fungal growth, asexual and sexual development, and conidia formation in A. nidulans.


asexual development velvet beta-glucan Aspergillus nidulans 


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The work by HSP was supported by the National Research Foundation of Korea (NRF) grant to HSP funded by the Korean government (NRF-2016R1C1B2010945). The work at UW-Madison (JHY) was primarily supported by the Intelligent Synthetic Biology Center of Global Frontier Project funded by the Ministry of Education, Science and Technology of Korea (No. 2011-0031955). The work by MKL was supported by the KRIBB Research Initiative Program (KGM-5231921).

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Copyright information

© The Microbiological Society of Korea 2019

Authors and Affiliations

  • Min-Ju Kim
    • 1
  • Won-Hee Jung
    • 1
  • Ye-Eun Son
    • 1
  • Jae-Hyuk Yu
    • 2
    • 3
  • Mi-Kyung Lee
    • 4
  • Hee-Soo Park
    • 1
    Email author
  1. 1.School of Food Science and Biotechnology, Institute of Agricultural Science and TechnologyKyungpook National UniversityDaeguRepublic of Korea
  2. 2.Departments of Bacteriology and GeneticsUniversity of WisconsinMadisonUSA
  3. 3.Department of Systems BiotechnologyKonkuk UniversitySeoulRepublic of Korea
  4. 4.Biological Resource Center (BRC)Korea Research Institute of Bioscience and Biotechnology (KRIBB)JeongeupRepublic of Korea

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