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Journal of Microbiology

, Volume 55, Issue 5, pp 396–402 | Cite as

N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection

  • Sungil Jang
  • Eun-Jung Bak
  • Jeong-Heon Cha
Microbial Pathogenesis and Host-Microbe Interaction

Abstract

Helicobacter pylori (H. pylori) is a human gastric pathogen, causing various gastric diseases ranging from gastritis to gastric adenocarcinoma. It has been reported that combining N-acetylcysteine (NAC) with conventional antibiotic therapy increases the success rate of H. pylori eradication. We evaluated the effect of NAC itself on the growth and colonization of H. pylori, and development of gastritis, using in vitro liquid culture system and in vivo animal models. H. pylori growth was evaluated in broth culture containing NAC. The H. pylori load and histopathological scores of stomachs were measured in Mongolian gerbils infected with H. pylori strain 7.13, and fed with NAC-containing diet. In liquid culture, NAC inhibited H. pylori growth in a concentration-dependent manner. In the animal model, 3-day administration of NAC after 1 week from infection reduced the H. pylori load; 6-week administration of NAC after 1 week from infection prevented the development of gastritis and reduced H. pylori colonization. However, no reduction in the bacterial load or degree of gastritis was observed with a 6-week administration of NAC following 6-week infection period. Our results indicate that NAC may exert a beneficial effect on reduction of bacterial colonization, and prevents the development of severe inflammation, in people with initial asymptomatic or mild H. pylori infection.

Keywords

gastritis Helicobacter pylori mongolian gerbil N-acetylcysteine 

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Copyright information

© The Microbiological Society of Korea and Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Oral Biology, Oral Science Research Center, BK21 PLUS ProjectYonsei University College of DentistrySeoulRepublic of Korea
  2. 2.Microbiology and Molecular Biology, Key Laboratory of Oral Medicine, Guangzhou Institute of Oral DiseaseStomatology Hospital of Guangzhou Medical UniversityShanghaiP. R. China

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