Journal of Microbiology

, Volume 52, Issue 12, pp 983–989 | Cite as

Protective role of gut commensal microbes against intestinal infections

  • My Young Yoon
  • Keehoon Lee
  • Sang Sun YoonEmail author


The human gastrointestinal tract is colonized by multitudes of microorganisms that exert beneficial effects on human health. Mounting evidence suggests that intestinal microbiota contributes to host resistance against enteropathogenic bacterial infection. However, molecular details that account for such an important role has just begun to be understood. The commensal microbes in the intestine regulate gut homeostasis through activating the development of host innate immunity and producing molecules with antimicrobial activities that directly inhibit propagation of pathogenic bacteria. Understanding the protective roles of gut microbiota will provide a better insight into the molecular basis that underlies complicated interaction among host-pathogen-symbiont. In this review, we highlighted recent findings that help us broaden our knowledge of the intestinal ecosystem and thereby come up with a better strategy for combating enteropathogenic infection.


gut microbiota enteropathogenic bacterial infection colonization resistance 


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Copyright information

© The Microbiological Society of Korea and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • My Young Yoon
    • 1
    • 3
  • Keehoon Lee
    • 1
    • 2
  • Sang Sun Yoon
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Microbiology and ImmunologyYonsei University College of MedicineSeoulRepublic of Korea
  2. 2.Brain Korea 21 Project for Medical SciencesYonsei University College of MedicineSeoulRepublic of Korea
  3. 3.Institute for Immunology and Immunological DiseasesYonsei University College of MedicineSeoulRepublic of Korea

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