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Journal of Microbiology

, Volume 52, Issue 6, pp 521–526 | Cite as

Antiviral activity of 3,4’-dihydroxyflavone on influenza a virus

  • Mohammed Kawser Hossain
  • Hye Yeon Choi
  • Jae-Seon Hwang
  • Ahmed Abdal Dayem
  • Jung-Hyun Kim
  • Young Bong Kim
  • Haryoung Poo
  • Ssang-Goo ChoEmail author
Article

Abstract

Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2᾿dihydroxyflavone (3,2᾿DHF) and 3,4᾿dihydroxyflavone (3,4᾿DHF), showed potent anti-influenza activity. They inhibited viral neuraminidase activity and viral adsorption onto cells. To confirm the anti-influenza activity of these flavonoids, we used an in vivo mouse model. In mice infected with human influenza, oral administration of 3,4᾿DHF significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death. Our data suggest that 3-hydroxyl group flavonoids, particularly 3,4᾿DHF, have potent antiviral activity against human influenza A/PR/8/34 (H1N1) in vitro and in vivo. Further clinical studies are needed to investigate the therapeutic and prophylactic potential of the 3-hydroxyl group flavonoids in treating influenza pandemics.

Keywords

flavonoid 3-hydroxyl group flavonoids 3,4᾿dihydroxyflavone influenza virus 

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Copyright information

© The Microbiological Society of Korea and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Mohammed Kawser Hossain
    • 1
  • Hye Yeon Choi
    • 1
  • Jae-Seon Hwang
    • 3
  • Ahmed Abdal Dayem
    • 1
  • Jung-Hyun Kim
    • 1
  • Young Bong Kim
    • 2
  • Haryoung Poo
    • 3
  • Ssang-Goo Cho
    • 1
    Email author
  1. 1.Department of Animal Biotechnology, Animal Resources Research Center, and Incurable Disease Animal model and Stem cell Institute (IDASI)Konkuk UniversitySeoulRepublic of Korea
  2. 2.Department of Bioindustrial TechnologiesKonkuk UniversitySeoulRepublic of Korea
  3. 3.Korea Research Institute of Bioscience and BiotechnologyDaejeonRepublic of Korea

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