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Journal of Microbiology

, Volume 52, Issue 1, pp 64–70 | Cite as

Cyclic dipeptides from lactic acid bacteria inhibit the proliferation of pathogenic fungi

  • Min-Kyu Kwak
  • Rui Liu
  • Min-Kyu Kim
  • Dohyun Moon
  • Andrew HyoungJin Kim
  • Sung-Hyun Song
  • Sa-Ouk KangEmail author
Microbial Physiology and Biochemistry

Abstract

Lactobacillus plantarum LBP-K10 was identified to be the most potent antifungal strain from Korean traditional fermented vegetables. The culture filtrate of this strain showed remarkable antifungal activity against Ganoderma boninense. Five fractions from the culture filtrate were observed to have an inhibitory effect against G. boninense. Also, the electron ionization and chemical ionization indicated that these compounds might be cyclic dipeptides. Of the five active fractions, two fractions showed the most significant anti-Ganoderma activity, and one of these fractions inhibited the growth of Candida albicans. These compounds were identified to be cis-cyclo(l-Val-l-Pro) and cis-cyclo(l-Phe-l-Pro), as confirmed by X-ray crystallography.

Keywords

Lactobacillus plantarum LBP-K10 culture filtrate, cis-cyclo(l-Val-l-Pro) cis-cyclo(l-Phe-l-Pro) Ganodermaboninense Candida albicans 

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Copyright information

© The Microbiological Society of Korea and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Min-Kyu Kwak
    • 1
  • Rui Liu
    • 1
  • Min-Kyu Kim
    • 1
  • Dohyun Moon
    • 2
  • Andrew HyoungJin Kim
    • 1
  • Sung-Hyun Song
    • 1
  • Sa-Ouk Kang
    • 1
    Email author
  1. 1.Laboratory of Biophysics, School of Biological Sciences, and Institute of MicrobiologySeoul National UniversitySeoulRepublic of Korea
  2. 2.Beamline Division, X-ray Research II Team at Pohang Accelerator LaboratoryPOSTECHPohangRepublic of Korea

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