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Journal of Microbiology

, Volume 51, Issue 3, pp 389–393 | Cite as

The effect of dietary intake of the acidic protein fraction of bovine colostrum on influenza A (H1N1) virus infection

  • Mei Ling Xu
  • Hyoung Jin Kim
  • Don Yong Chang
  • Hong-Jin Kim
Virology

Abstract

Acidic protein levels in the milk decrease markedly as lactation progresses, suggesting that it is an important part of the colostrum. However, little attention has been paid to their biological function. In this study, we isolated the acidic protein fraction of bovine colostrum (AFC, isoelectric point <5) by anion-exchange chromatography, and investigated the effect of its dietary intake on influenza A (H1N1) virus infection. 100% of mice infected with 1 LD50 of the virus survived when administered AFC for 14 days prior to infection, compared with 33% survival when administered phosphate buffered saline (PBS). Moreover, consumption of AFC reduced the weight loss associated with infection. We propose that dietary intake of AFC has a prophylactic effect on influenza A virus infection.

Keywords

bovine colostrums acidic protein dietary intake influenza A virus 

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Copyright information

© The Microbiological Society of Korea and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Mei Ling Xu
    • 1
  • Hyoung Jin Kim
    • 1
  • Don Yong Chang
    • 1
  • Hong-Jin Kim
    • 1
  1. 1.College of PharmacyChung-Ang UniversitySeoulRepublic of Korea

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