The Journal of Microbiology

, Volume 46, Issue 6, pp 744–750

Inhibitory effect of methyl gallate and gallic acid on oral bacteria

  • Mi-Sun Kang
  • Jong-Suk Oh
  • In-Chol Kang
  • Suk-Jin Hong
  • Choong-Ho Choi


This study examined the ability of methyl gallate (MG) and gallic acid (GA), the main compounds of gallo-tannins in Galla Rhois, to inhibit the proliferation of oral bacterial and the in vitro formation of Streptococcus mutans biofilms. The antimicrobial activities of these compounds were evaluated in vitro using the broth microdilution method and a beaker-wire test. Both MG and GA had inhibitory effects on the growth of cariogenic (MIC<8 mg/ml) and periodontopathic bacteria (MIC=1 mg/ml). Moreover, these compounds significantly inhibited the in vitro formation of S. mutans biofilms (MG, 1 mg/ml; GA, 4 mg/ml; P<0.05). MG was more effective in inhibiting bacterial growth and the formation of S. mutans biofilm than GA. In conclusion, MG and GA can inhibit the growth of oral pathogens and S. mutans biofilm formation, and may be used to prevent the formation of oral biofilms.


antibacterial activity Galla Rhois gallic acid methyl gallate oral bacteria 


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Copyright information

© The Microbiological Society of Korea and Springer-Verlag Berlin Heidelber GmbH 2008

Authors and Affiliations

  • Mi-Sun Kang
    • 1
  • Jong-Suk Oh
    • 1
  • In-Chol Kang
    • 2
    • 3
  • Suk-Jin Hong
    • 3
    • 4
  • Choong-Ho Choi
    • 3
    • 4
  1. 1.Department of Microbiology, School of MedicineChonnam National UniversityGwangjuRepublic of Korea
  2. 2.Brain Korea 21 ProgramChonnam National UniversityGwangjuRepublic of Korea
  3. 3.Dental Science Research InstituteChonnam National UniversityGwangjuRepublic of Korea
  4. 4.Department of Preventive and Public Health DentistryChonnam National UniversityGwangjuRepublic of Korea

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