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Stimuli-responsive nitric oxide generator for light-triggered synergistic cancer photothermal/gas therapy

  • Xuehui Huang
  • Funeng Xu
  • Huabo Hou
  • Jianwen Hou
  • Yi WangEmail author
  • Shaobing ZhouEmail author
Research Article
  • 23 Downloads

Abstract

As a minimally invasive local cancer therapy, photothermal therapy (PTT) has aroused intensive interests in recent years. However, the therapeutic effect of PTT is still unsatisfying due to the production of heat shock proteins. Combination therapy has been regarded as a promising strategy to enhance therapeutic efficiency. In this study, a novel intelligent protoporphyrin (PpIX)-based polymer nanoplatform is developed for synergistic enhancement of cancer treatment through combined PTT and nitric oxide (NO) therapy. The core of the nanoparticle is composed of closely packed porphyrin-based NO donors and PpIX branches of the block copolymer. The prepared nanoparticles exhibit good photothermal conversion capability and high sensitivity to release NO under light illumination. And the produced high localized temperature and intracellular NO concentration could efficiently inhibit cancer cells both in vitro and in vivo. More important, this therapeutic nanoplatform can fundamentally eliminate the emergence of multidrug resistance and overcome the hypoxia microenvironment in tumors because of the absence of chemotherapeutic drugs and the oxygen-independent process, thus opening up new ideas for multifunctional therapeutic agent design for treatment of multidrug-resistant cancer.

Keywords

photothermal therapy gas therapy micelles combination therapy nanocarrier 

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Notes

Acknowledgements

This work was partially supported by the National Key Research and Development Program of China (No. 2017YFB0702602), the China National Funds for Distinguished Young Scientists (No. 51725303), the National Natural Science Foundation of China (Nos. 21574105, 51603172, and 81701831) and the Sichuan Province Youth Science and Technology Innovation Team (No. 2016TD0026).

Supplementary material

12274_2019_2307_MOESM1_ESM.pdf (2.7 mb)
Stimuli-responsive nitric oxide generator for light-triggered synergistic cancer photothermal/gas therapy

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Copyright information

© Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduChina
  2. 2.School of Life Science and EngineeringSouthwest Jiaotong UniversityChengduChina

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