Single ultrasmall Mn2+-doped NaNdF4 nanocrystals as multimodal nanoprobes for magnetic resonance and second near-infrared fluorescence imaging
- 241 Downloads
Multimodal imaging probes have attracted wide attention and have potential to diagnose diseases accurately because of the complementary advantages of multiple imaging modalities. However, intractable issues remain with regard to their complicated multi-step fabrication for hybrid nanostructure and interference of different modal imaging. In the present study, we present, for the first time, T1 and T2-weighted magnetic resonance imaging (MRI) of ultrasmall Mn2+-doped NaNdF4 nanocrystals (NCs), which can also be used simultaneously for second near infrared (NIR-II) fluorescence and computed tomography (CT) imaging, thus enabling high-performance multimodal MRI/NIR-II/CT imaging of single NaNdF4:Mn NCs. The NaNdF4:Mn was demonstrated as a nanoprobe for in vitro and in vivo multimodal MRI and NIR-II fluorescence imaging of human mesenchymal stem cells. The results provide a new strategy to simplify the nanostructure and preparation of probes, based on the features of NaNdF4:Mn NCs, which offer highly efficient multimodal MRI/NIR-II/CT imaging.
KeywordsNaNdF4:Mn ultrasmall nanoprobe magnetic resonance imaging (MRI) second near infrared (NIR-II) fluorescence multimodal imaging
Unable to display preview. Download preview PDF.
The work was supported financially by the National Natural Science Foundation of China (Nos. 11174324 and 10804082) and by the Youth Innovation Promotion Association of Chinese Academy of Sciences (No. 2011235).
- Hong, G. S.; Zou, Y. P.; Antaris, A. L.; Diao, S.; Wu, D.; Cheng, K.; Zhang, X. D.; Chen, C. X.; Liu, B.; He, Y. H. et al. Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window. Nat. Commun. 2014, 5, 4206.Google Scholar
- Benayas, A.; Ren, F. Q.; Carrasco, E.; Marzal, V.; del Rosal, B.; Gonfa, B. A.; Juarranz, A.; Sanz-Rodríguez, F.; Jaque, D.; García-Solé, J. et al. PbS/CdS/ZnS quantum dots: A multifunctional platform for in vivo near-infrared lowsose fluorescence imaging. Adv. Funct. Mater. 2015, 25, 6650–6659.CrossRefGoogle Scholar
- Rocha, U.; Kumar, K. U.; Jacinto, C.; Villa, I.; Sanz-Rodríguez, F.; de la Cruz, M. D. C. I.; Juarranz, A.; Carrasco, E.; van Veggel, F. C. J. M.; Bovero, E. et al. Neodymium-doped LaF3 nanoparticles for fluorescence bioimaging in the second biological window. Small 2014, 10, 1141–1154.CrossRefGoogle Scholar
- Villa, I.; Vedda, A.; Cantarelli, I. X.; Pedroni, M.; Piccinelli, F.; Bettinelli, M.; Speghini, A.; Quintanilla, M.; Vetrone, F.; Rocha, U. et al. 1.3 μm emitting SrF2:Nd3+ nanoparticles for high contrast in vivo imaging in the second biological window. Nano Res. 2015, 8, 649–665.CrossRefGoogle Scholar
- Zeng, S. J.; Yi, Z. G.; Lu, W.; Qian, C.; Wang, H. B.; Rao, L.; Zeng, T. M.; Liu, H. R.; Liu, H. J.; Fei, B. et al. Simultaneous realization of phase/size manipulation, upconversion luminescence enhancement, and blood vessel imaging in multifunctional nanoprobes through transition metal Mn2+ doping. Adv. Funct. Mater. 2014, 24, 4051–4059.CrossRefGoogle Scholar
- Kim, T.; Momin, E.; Choi, J.; Yuan, K.; Zaidi, H.; Kim, J.; Park, M.; Lee, N.; McMahon, M. T.; Quinones-Hinojosa, A. et al. Mesoporous silica-coated hollow manganese oxide nanoparticles as positive T 1 contrast agents for labeling and MRI tracking of adipose-derived mesenchymal stem cells. J. Am. Chem. Soc. 2011, 133, 2955–2961.CrossRefGoogle Scholar