Nano Research

, Volume 7, Issue 6, pp 844–852 | Cite as

Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes

  • Dong Hyun Jo
  • Jin Hyoung Kim
  • Jin Gyeong Son
  • Yuanze Piao
  • Tae Geol LeeEmail author
  • Jeong Hun KimEmail author
Research Article


Nanoparticles can be involved in biological activities such as apoptosis, angiogenesis, and oxidative stress by themselves. In particular, inorganic nanoparticles such as gold and silica nanoparticles are known to inhibit vascular endothelial growth factor (VEGF)-mediated pathological angiogenesis. In this study, we show that anti-angiogenic effect of inorganic nanospheres is determined by their sizes. We demonstrate that 20 nm size gold and silica nanospheres suppress VEGF-induced activation of VEGF receptor-2, in vitro angiogenesis, and in vivo pathological angiogenesis more efficiently than their 100 nm size counterparts. Our results suggest that modulation of the size of gold and silica nanospheres determines their inhibitory activity to VEGF-mediated angiogenesis.


nanospheres anti-angiogenesis effects inorganic nanoparticles vascular endothelial growth factor pathological angiogenesis 


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Copyright information

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Dong Hyun Jo
    • 1
    • 2
  • Jin Hyoung Kim
    • 1
  • Jin Gyeong Son
    • 3
    • 4
  • Yuanze Piao
    • 5
    • 6
  • Tae Geol Lee
    • 3
    Email author
  • Jeong Hun Kim
    • 1
    • 2
    • 7
    Email author
  1. 1.Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research InstituteSeoul National UniversitySeoulRepublic of Korea
  2. 2.Department of Biomedical Sciences, College of MedicineSeoul National UniversitySeoulRepublic of Korea
  3. 3.Center for Nano-Bio Convergence, World Class LaboratoryKorea Research Institute of Standards and ScienceDaejeonRepublic of Korea
  4. 4.Department of Chemistry and KI for the NanoCenturyKAISTDaejeonRepublic of Korea
  5. 5.Graduate School of Convergence Science and TechnologySeoul National UniversitySeoulKorea
  6. 6.Advanced Institutes of Convergence TechnologySuwonRepublic of Korea
  7. 7.Department of Ophthalmology, College of MedicineSeoul National UniversitySeoulRepublic of Korea

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