Potential molecular mechanisms underlying the effect of arsenic on angiogenesis

  • Juan Zhang
  • Yue Zhang
  • Weiyan Wang
  • Zhiyi ZhangEmail author


Arsenic is a potent chemotherapeutic drug that is applied as a treatment for cancer; it exerts its functions through multiple pathways, including angiogenesis inhibition. As angiogenesis is a critical component of the progression of many diseases, arsenic is a feasible treatment option for patients with other angiogenic diseases, including rheumatoid arthritis and psoriasis, among others. However, arsenic is also a well-known carcinogen, demonstrating a pro-angiogenesis effect. This review will focus on the dual effects of arsenic on neovascularization and the relevant mechanisms underlying these effects, aiming to provide a rational understanding of arsenic treatment. In particular, we expect to provide a comprehensive overview of the current knowledge of the mechanisms by which arsenic influences angiogenesis.


Arsenic trioxide Arsenite Cancer Angiogenesis Toxicity 



This work is supported by National Natural Science Foundation of China (NSFC 81771749) to Zhiyi Zhang, Chinese Postdoctoral Science Foundation (Grant No. 2019M651309) to Juan Zhang, Heilongjiang Provincial Postdoctoral Science Foundation (Grant No. LBH-Z18226) to Juan Zhang, and Scientific Research Innovation Foundation of the First Affiliated Hospital of Harbin Medical University (Grant No. 2019B18) to Juan Zhang.

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest.


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© The Pharmaceutical Society of Korea 2019

Authors and Affiliations

  1. 1.Department of Rheumatology, The First Affiliated HospitalHarbin Medical UniversityHarbinChina

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