Archives of Pharmacal Research

, Volume 42, Issue 8, pp 732–734 | Cite as

Correction to: Pharmacology of natural radioprotectors

  • Gil-Im Mun
  • Seoyoung Kim
  • Eun Choi
  • Cha Soon KimEmail author
  • Yun-Sil LeeEmail author
Open Access

Correction to: Arch. Pharm. Res.

We apologize that there are some errors in the references for three sentences and table 2.

  1. 1.

    In the section “Naturally occurring radioprotectors”, the reference of the first paragraph’s last sentence should be changed from ‘(Yu et al. 2003)’ to ‘(Praetorius and Mandal 2008)’.


Indeed, amifostine has several clinically relevant limitations, including (1) an administration time within a narrow window (15–30 min before IR exposure); (2) approval only for intravenous (IV) administration (Praetorius and Mandal 2008); and (3) high toxicity associated with undesirable side effects including nausea, vomiting, cephalalgia, and hypotension.

  1. 2.

    In the section “Ferulic acid”, the reference of sixth sentence should be changed from ‘(Srinivasan et al. 2006)’ to ‘(Prasad et al. 2006)’.


Pretreatment of lymphocytes and hepatocytes with ferulic acid resulted in a significant decrease in DNA damage and lipid peroxidation after IR exposure (Prasad et al. 2006).

  1. 3.

    In the section “Hesperidin”, the reference of fourth sentence should be changed from ‘(Fardid et al. 2016)’ to ‘(Hosseinimehr et al. 2009)’.


Additionally, hesperidin was shown to protect against genetic damage to lymphocytes induced by the radiotracer 99mTc-MIBI in vitro (Hosseinimehr et al. 2009).

  1. 4.
    In connection to these errors, the following articles should be deleted in the References section:
    • Fardid R, Ghorbani Z, Haddadi G, Behzad-Behbahani A, Arabsolghar R, Kazemi E, Okhovat MA, Hosseinimehr SJ (2016) Effects of hesperidin as a radio-protector on apoptosis in rat peripheral blood lymphocytes after gamma radiation. J Biomed Phys Eng 6:217–228

    • Srinivasan M, Rajendra Prasad N, Menon VP (2006) Protective effect of curcumin on gamma-radiation induced DNA damage and lipid peroxidation in cultured human lymphocytes. Mutat Res 611:96–103

    • Yu Z, Eaton JW, Persson HL (2003) The radioprotective agent, amifostine, suppresses the reactivity of intralysosomal iron. Redox Rep 8:347–355

  1. 5.
    Instead, following articles should be added to the References section:
    • Hosseinimehr SJ, Ahmadi A, Beiki D, Habibi E, Mahmoudzadeh A (2009) Protective effects of hesperidin against genotoxicity induced by 99mTc-MIBI in human cultured lymphocyte cells. Nucl Med Biol 36:863–867

    • Praetorius NP, Mandal TK (2008) Alternate delivery route for amifostine as a radio-/chemo-protecting agent. J Pharm Pharmacol 60:809–815

    • Prasad NR, Srinivasan M, Pugalendi KV, Menon VP (2006) Protective effect of ferulic acid on gamma-radiation-induced micronuclei, dicentric aberration and lipid peroxidation in human lymphocytes. Mutat Res 603:129–134

  1. 6.
    In Table 2, three references should be corrected.
    • ‘Hall and Giaccia (2012)’ for caffeine should be corrected to ‘Kamat et al. (2000)’.

    • ‘Farooqi and Kesavan (1992)’ should be added for caffeine.

    • ‘Fardid et al. (2016)’ for hesperidin should be corrected to ‘Shaban et al. (2017)’.

Table 2

List of naturally occurring compounds with radioprotective effects

Natural compounds


Radioprotective effects



Parsley, Celery, Chamomile

Anti-inflammatory, anti-proliferative, and anti-progression

Begum et al. (2012)


Caesalpinia digyna

Activation of the MAP kinase and ERK pathways and protection against radiation damage

Dwivedi et al. (2017)

Veerapur et al. (2009)


Coffee beans

Protection against the oxic component of damage in rat liver mitochondria

Inhibition of radiation-mediated chromosomal aberrations in mouse bone marrow cells

Farooqi and Kesavan (1992)

Kamat et al. (2000)

Chlorogenic acid/quinic acid

Cinchona bark, Coffee beans

Anti-inflammation, anti-mutagenic, DNA damage inhibition, and anti-oxidation

Cinkilic et al. (2013)

Coniferyl aldehyde

Eucommia ulmoides

Induction of heat shock transcription factor 1 and protection against radiation damage

Kim et al. (2015)

Nam et al. (2013)


Turmeric root

Reduction of gastrointestinal symptoms during chemotherapy and radiation therapy

Reduction of mucositis during radiation therapy

Reduction of radiation dermatitis and desquamation

Verma (2016)


Carrot, Tomato, Red onion, Cranberries, Concord grapes, etc

Anti-oxidation and anti-inflammation

Jeong et al. (2016)

Watson and Schonlau (2015)


Camellia sinensis

Increased levels of several anti-oxidant enzymes

Protection of skin cells against radiation-induced damage and radioprotective effects against several radiation-mediated responses

Zhang et al. (2016)

Zhu et al. (2016)

Ferulic acid

Rice, Green tea, Coffee beans

Protection against radiation-induced damage and enhancement of DNA repair

Prevention of radiation-induced micronuclei and dicentric aberrations in human lymphocytes

Enhancement of survival in mice after radiation

Das et al. (2014)

Kikuzaki et al. (2002)

Zhao et al. (2003)


Genista tictoria, etc.

Protection against acute radiation injury

Multiple mechanisms (e.g., antioxidant, free radical scavenger, anti-inflammatory, activation of the DNA repair enzyme Gadd45

Ahmad et al. (2010)

Davis et al. (2007)

Grace et al. (2007)


Citrus fruit

Efficient radioprotection in rat lung tissue

Protection of lipid peroxidation during radiation-induced tissue damage in rats

Rezaeyan et al. (2016)

Shaban et al. (2017)


Tomato, Watermelon, Pink grapefruit, Papaya, etc

Protection against radiation-induced chromosomal damage in human lymphocytes

Increased survival after radiation exposure

Kelkel et al. (2011)

Srinivasan et al. (2009)

N-Acetyl tryptophan glucopyranoside (NATG)

Bacillus subtilis

Overcoming radiation-induced apoptosis by improving cytoprotective cytokines

Enhancement of antioxidant enzymes against radiation-induced damage

Malhotra et al. (2015)

Malhotra et al. (2018)


Psoralea corylifolia

Inhibition of radiation-induced PI3K-IKK-IκB signaling pathway and COX-2 expression

Suppression of radiation-induced expression of pro-inflammatory cytokines

Chiou et al. (2011)

Yang et al. (2011)


Sesame seeds, Sesame oil

Strong ROS scavenging and antioxidant properties

Kanimozhi and Prasad (2009)

Mishra et al. (2011)


Sophora japonica

Protection against radiation-induced damage to the salivary glands and mucosa

Inhibition of lipid peroxidation in the membranes of subcellular organelles

Differential protection of normal cells in irradiated tumor-bearing mice: protection in blood leukocytes and bone marrow cells but not in tumor cells

Maurya et al. (2004)


Vanilla orchid (Vanilla planifolia, V. fragrans)

Suppression of radiation-induced chromosomal aberrations in cells and in mice

Anti-mutagenic effects

Kumar et al. (2000)




Ahmad et al. (2015)

Rao and Rao (2010)

Zymosan A

Saccharomyces cerevisiae

Protection from radiation-induced apoptosis by upregulating the levels of cytokines

Protection of cells from radiation-induced DNA damage

Du et al. (2018)


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© The Author(s) 2019

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Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Authors and Affiliations

  1. 1.Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulKorea
  2. 2.Radiation Health InstituteKorea Hydro & Nuclear Power CO., LTDSeongnam-siKorea

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