Archives of Pharmacal Research

, Volume 42, Issue 6, pp 466–480 | Cite as

Bookmarking by histone methylation ensures chromosomal integrity during mitosis

  • Ja-Eun KimEmail author


The cell cycle is an orchestrated process that replicates DNA and transmits genetic information to daughter cells. Cell cycle progression is governed by diverse histone modifications that control gene transcription in a timely fashion. Histone modifications also regulate cell cycle progression by marking specific chromatic regions. While many reviews have covered histone phosphorylation and acetylation as regulators of the cell cycle, little attention has been paid to the roles of histone methylation in the faithful progression of mitosis. Indeed, specific histone methylations occurring before, during, or after mitosis affect kinetochore assembly and chromosome condensation and segregation. In addition to timing, histone methylations specify the chromatin regions such as chromosome arms, pericentromere, and centromere. Therefore, spatiotemporal programming of histone methylations ensures epigenetic inheritance through mitosis. This review mainly discusses histone methylations and their relevance to mitotic progression.


Histone modification Histone methylation Epigenetics Cell cycle Mitosis Chromosomal stability 



We thank all authors of the works referenced in this article, and apologize that we cannot list all of them due to space limitations. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (2018R1A2A2A05022043).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© The Pharmaceutical Society of Korea 2019

Authors and Affiliations

  1. 1.Department of Pharmacology, School of MedicineKyung Hee UniversitySeoulRepublic of Korea

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